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Max Planck Institut for Heart and Lung Research is Looking for Phd or RA
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Group Leader: Johnny Kim Distinct organs often contain a resident population of organ-specific stem cells that enable tissue-specific regeneration throughout most of adult life. Recent findings suggest that cell fate decisions made by cells in their past are not irrevocable but might be reverted and reprogrammed. This dynamic concept of a cell’s fate corresponds with the established view that maintenance of a cellular phenotype does not reflect a static state but rather requires continuous regulation. This phenomenon enables to redirect and manipulate cells and enhance regenerative properties of tissues and organs provided that the molecular mechanisms in regulating cellular phenotype are known. A major goal of our research is to elucidate processes that govern the self-renewal and coordinated differentiation of stem cells during development and regeneration. We aim at reaching an understanding of stem cell mediated tissue regeneration and of how defects in these processes can lead to the manifestation of human disease or to the progressive loss of regenerative potential during disease and physiological aging. To this end, we employ a systems biology approach and integrate a broad spectrum of tools to understand the molecular mechanisms involved in determining cell fate decisions. These tools include: 1) quantitative omics-level profiling of FACS purified primary stem cells 2) the development and execution of functional high-throughput screens 3) the development and analysis of in vitro models and tissue specific knockout mice. The successful candidate are invited from candidates with a Master's degree (or equivalent) in biological, cancer sciences or a related discipline. As a minimum, you should hold, or expect to obtain, a first or upper second class undergraduate degree or equivalent(GPA>3.0), in an appropriate subject from a recognised academic institution. The ideal candidates desired to have experiences about Molecular biology such as cell culture, IPS/ES cells, Plasmid constructions, qRT-PCR, animal experiments. TOTEL>85 or IELTS>6.5 or GRE>310 The successful candidate will be fully-funded by International max planck research schools. Please Include CV to Jiasheng.Zhong@mpi-bn.mpg.de if you interest |
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2楼2017-06-03 03:17:24