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westlover

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Improved osseointegration of long-term stored SLA implant by hydrothermal sterilization.

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westlover

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westlover: 金币+5 2017-05-22 08:59:26
lazy锦溪: LS-EPI+1 2017-05-22 13:52:44
Improved osseointegration of long-term stored SLA implant by hydrothermal sterilization
作者:Shi, XL (Shi, Xingling)[ 1 ] ; Xu, LL (Xu, Lingli)[ 1 ] ; Violin, KB (Violin, Kalan Bastos)[ 2 ] ; Lu, S (Lu, Sheng)[ 1 ]
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷: 53  页: 312-319
DOI: 10.1016/j.jmbbm.2015.08.038
出版年: JAN 2016
查看期刊信息
摘要
The sandblasted, large-grit and acid-etched (SLA) surface is easy to be contaminated during storage and its surface chemical state is usually changed by different sterilization methods. This causes an undesirable increase in surface hydrophobicity and results in osseointegration degradation. To overcome this problem, a low temperature hydrothermal (HT) sterilization method was proposed in this study. Briefly, 4 weeks-stored pure titanium SLA specimens were sterilized using a sealed glass bottle with pure water in an autoclave set at 121 degrees C for 20 min. Results showed that, stored SLA specimens were superhydrophobic before and after conventional autoclaving, whereas, HT sterilization decontaminated and endowed stored SLA surface with superhydrophilicity. Osteoblast spreading was greatly enhanced, ALP expression was upgraded and bone nodule formation was obviously promoted on HT sterilized specimens compared with autoclaved ones. More bone formation around HT sterilized specimens was observed and HT sterilization increased bonding strength of implant to bone by 95% and 127% after 2 and 4 weeks of healing, respectively. The simple, feasible HT sterilization restored osseointegration of SLA implant while diminishing recontamination as much as possible. Therefore, it is proposed as a standard sterilization method for implant practitioners and researches. (C) 2015 Elsevier Ltd. All rights reserved.
关键词
作者关键词:SLA implant; Hydrothermal sterilization; Autoclaving; Superhydrophilicity; Osseointegration
KeyWords Plus:SURFACE-PROPERTIES; TITANIUM SURFACES; DENTAL IMPLANTS; BONE-MARROW; CELLS; BIOMATERIAL; EXPRESSION; RESPONSES
作者信息
通讯作者地址: Xu, LL (通讯作者)
显示增强组织信息的名称        Jiangsu Univ Sci & Technol, Sch Mat Sci & Engn, Zhenjiang 212003, Peoples R China.
地址:
显示增强组织信息的名称        [ 1 ] Jiangsu Univ Sci & Technol, Sch Mat Sci & Engn, Zhenjiang 212003, Peoples R China
显示增强组织信息的名称        [ 2 ] Mat Sci & Technol Ctr, Energy & Nucl Res Inst, BR-05508000 Sao Paulo, Brazil
电子邮件地址:linly311@163.com
基金资助致谢
基金资助机构        授权号
Jiangsu Provincial Key Laboratory for Interventional Medical Devices        
jr1418
Ph.D. programs foundation of the Jiangsu University of Science and Technology        
635061402
查看基金资助信息   
出版商
ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
类别 / 分类
研究方向:Engineering; Materials Science
Web of Science 类别:Engineering, Biomedical; Materials Science, Biomaterials
文献信息
文献类型:Article
语种:English
入藏号: WOS:000366226500028
PubMed ID: 26382972
ISSN: 1751-6161
eISSN: 1878-0180
其他信息
IDS 号: CY2GJ
Web of Science 核心合集中的 "引用的参考文献": 27
Web of Science 核心合集中的 "被引频次": 2
知识就像蒲公英的花儿一样,播种在世界的每一个角落。
3楼2017-05-21 13:30:17
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