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D7 ?? ??????Τλ???????????????? �?????γ???????????????u????????^????μ??? ?s?Τ????? �???????????Τ??????????????????????????? ???????θ??????????p????????????????????? ?????????????????????????�???????????????? �????A??Τ???????С??C??????????????? ????????A??????L?????????????? �???????????????????????????????????? ??k?????T?k???????μ????s?Τ????????V????? ??????k?????T?k??????????????? �???b?趨??12?L??????ыD???�?ыD???b?D??????D?? ????????????? �??????????????????????郹???�С????????? ??????? ?? ?M??・??? ????? ?Х??????????V 100� ???・???? ???V?У???????????100�???? ?????????`???????????????????? ?????? ?????????????`LD???饦????????? ??????????`??80?????????????? ???????? ?・???? ??????c???V?????????`???V?? ???? ???R?e???`??? ?????�?? 7.3 ???�?? 3.2 ?????�?? 137.0 ?? ????・???? �????????????????・????γ?????? ?????????????????????????????????? ????? ?????×??????????^??×????k????TIA????×?????? �????}?Х?????g??CABG????????U??U?????}?γ??g ??PTCA???????????????・????γ?????? �???鲡?????鲡????????????z???? ?? ?÷?・???? �?????????????????????????????????????????????? ??×??????????^??×????k????TIA????×????????????? ??・????γ???????????}?Х?????g??CABG?????? ??U??U?????}?γ??g??PTCA???????????????・?? ??γ???????????????? ??????????????????????100�?? 1 ?? 1 ??U??? ???? ??????????? 1 ??300�??????????? �???鲡?????鲡????????????z??????????????? ???????П????g??????????????? 1 ?????? 1 kg?????? 30??50�?? 3 ???????U????????????λ?????? ?????????????????????? 1 ?????? 1 kg?????? 3 ?? 5 �?? 1 ??U??????? ??????????????m?ˉ??p???? ?÷?・???????v?B????????????? �??????????????×??????????γ??????????? ??????С???????k?F?????????????????r ????????????????????Z????????????? ????R????? �?R???a??????????? �????????????U??U?????}?γ??g??PTCA????? ????γ?????????????????????????????????? ????????????1???? �??t???????鲡???\???????ε???????_????? ?????????????? �???鲡???k??????????g???С????????????M???? ????Τ?????鲡?λ??????????????????k??? 2 ?? 3 ?????g???????????????????`????ι???} ???ǹ???}??????J???????????????????? ?????????????????}?????γ????????????? ???}??????s???_?J?????r????????@?A???? ???????????? �???鲡???????????????????????????С??C?? ????????J????????????????m????С?? ??????Μy?????]??????? ?? ????????? �????????Τλ?????????????????? �???????????μ????s?Τ????????????????????k?????? ??????????? �????????????μ????s?Τ????????????????? ???????k???????????????? �????A???????Τ?????????????????????? ?????? �??????????μ????s?Τ?????????????????????k ???????????????? �?I????????μ????s?Τ???????I??????????????k ???????????????? �????????Τ?????????????λ?????Ф??????? ?????????????????????λ???????V?? ????k?????T?k??????????????? �?????`?????????????????`?????r??? ??????????????????T?k??ω?????????????? ????�?????á?????????? �???h????�???h?????????????? �?ыD?????????????b?趨??12?L??????ыD??????????? ?路??????????Τ???D????�?ыD???b?D??????D?? ????????????? �С?????�С???????????????? �???g?????????`????????i?n? 1 ?L?g????λ??? ?????g?????????`????????i?n?r????????? ???????????????? �???????????????????????L?????????????????? ?Τ??????????????L??????????????????? ???????`???????????Ф?????????????? ????`???????????????????????????????????? ??????????・????????????????????????`??? ??????????????????????????????Τ???????? ?@?A??????????????U?^???Q???????????? ????????? �????????????? �???????????u???????g?B??????????????ΤΣ? ????????????????????u????饤????????v?B?? ?????????{???椬????Τ????????15?rδ????????? ????????λ?????????????????t????? ?????????????????????????????????? ??λ??????B???????Q??????2??????饤?????? 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Hours ????????? 10 ??????????? �?????????????????????c???V??325�?????Z????? ???????? ?????????????С????????????????????k?F???????? ????????????Θ?????n??6 10 1 2 3 4 5 67 89 10 11 12 13 hr ??15??????ADP???????????????С?????????? ?????r?g ???K???????Х??????????B2??TXB2???ε??¤??J??? ?? 11?????????????J?????????? �?R?????? 7,12??18?? �?????????????????????????????????????????????? 75??1,500�/?????????????????^??Y??????????? ?????k?????????????????????????¤??J?????? ???????????J??????????? �?????????????????????????75??325�/???????? ?????????^??Y???????????????k?????×???аk???? ??????????????????????¤??J???????????????? ?J??????????? �???????????????????????75??1,500�/???????? ?????????^??Y???????????????k?????×???аk???? ??????????????????????¤??J???????????????? ?J??????????? �??^??×????k????TIA????×??????λ??????×??????`?? ????????????????????30??1,500�/???????????? ?????^??Y???????????^??×????k???k?????×???? ?k?????????????????????¤??J???????????????? ?J??????????? �????}?Х?????g??CABG??????U??U?????}?γ??g??PTCA?? ????????????????50??1,500�/??????????????? ???^??Y??????????????????????]???k????????? ????k????????????¤??J?????????????????J???? ??????? �???鲡??????????????????????П????g???30??50� /kg/??????????????????????????????u??????????? ?????????g?????????x?k??????????? 5 �/kg/?????? ??????Y?????????????}?????k?????????????????? ?J???????? ???�??�?Υ?????????R????????????餫?????????v????J ???????????K????к??????k?F???X?p????????????? ?μ?????????????ε???????????75??350�/???????X????? ????7???? ?? ??????? ?V???? 100� PTP??? 500?V??10?V??50????700?V??14?V??50?? 1,000?V??10?V??100?? ?Х?????500?V ?? ??????? 1??Ryan, T. J. et al.??J. Am. Coll. Cardiol., 28??5??, 1328??1996?? 2?????????a????????a??????????No. 151??1998?? 3??Schauerte???Х??????a??????Y???1998?? 4??Sim, S. M. et al.??Br. J. Clin. Pharmac., 32, 17??1991?? 5?????????????Х??????a??????Y???1999?? 6??Degen, J. et al.???Х??????a??????Y???1994?? 7??Federal Register, 63??205??, 56802??October 23, 1998?? 8??Wilson, J. T. et al.??Clin. Pharmacol. Ther., 23, 635??1978?? 9??Pu??tter, J.??International symposium on present state of acetylsalicylic acid in research and therapeutic application, p49??1982?? 10??Ali, M. et al.??Stroke, 11, ??1980?? 11??Jimenez, A. H. et al.??Am. J. Cardiol., 69, 258??1992?? 12??Moerloose, Ph. de. et al.??Med. Et Hyg., 49, 82??1991?? 13??Born, G.V. R.??Z. Kardiol., 79, 147??1990?? 14??Silagy, C.??Drugs ?? Aging, 3, 301??1993?? 15??Patrono, C.??New Engl. J. Med., 330, 1287??1994?? 16??Lloyd, J. et al.??Aust. Prescriber 19, 79??1996?? 17??Sato, N. et al.??Pediatr. Int., 41, ??1999?? 18????????????????С????????j?I??87, 2486??1983?? 19??Lecomte, M. et al.??J. Biol. Chem., 269, 13207??1994?? 20??Gordon, J. L. et al.??Brit. J. Pharmac., 64, 481??1978?? 21?????????・???????a??? ??10?棨?V??????, 27??, p872 ??2003?? ?? ????????? ??????????d???????Y?????????????????????¤????? ?? ?a???a?? 19,20?? - ?Х??????a????????・??????????????`????? ??????????????????????????????`??1??COX 1?????躦?????? ??л??Υ?????????????????????????????A2??TXA2?? ????530-0001 ?????б???÷??????4?? 9?? ?κ????躦?????С?????????????????????С???????? ?? ?Х????????????a??Τ???????碌?? COX-1?躦???????С?夬???????????????????????? ?Х??????a????????・????????? � 0120 -106-398 ???????????????M?????COX-1????????Ф????? ????????????????PGI2??????躦????????????^????? ????????????????x??????????????COX-1???躦?????? ?С????????????????Ф??????????????Τ??????????????? ???????????????????? 21?? ?????Τ???? ?? ????????v????????????? ??????? CO2H O O CH3 ???????????????Aspirin?? ???????2-Acetoxybenzoic acid ???????C9H8O4 ????????180.16 ??????s136?? ??????????????νY??????????????????????????鷺 ??????ζ?????? ?????????Ω`??95????????????????????????? ?????`???????????????????????????? ??????????????????????????????? ????? ?????????????Ф???????????????????? ????????? ?? ?? 6 ?? |
3楼2017-04-14 16:33:34
【答案】应助回帖
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wangluo335: 金币+5, ★有帮助, 审评资料已经有了，想要制剂专利，谢谢 2017-04-17 08:32:04
wangluo335: 金币+5, ★有帮助, 审评资料已经有了，想要制剂专利，谢谢 2017-04-17 08:32:04
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