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Cmax tmax AUC t 1/2 ????g/L?? ??h?? ????g・h/L?? ??h?? ???????? 455.3 4.00 542.2 0.44 ????????? 6301.4 4.50 24843 2.03 ??????????? 498.8 4.75 2485.4 2.42 Cmax????????????tmax?????????????_?r?g AUC????????r?g????????e??t 1/2????p?? ??Cmax??AUC??t 1/2????????????tmax????????n??6 ?? ????????????c???V????????u????????????????V?????? ?^???????????W?????Τ????Х????????????????? tmax???L????Cmax?????? ?????7?? ????????????????U?????飬????M?????????νM???? ??????Ф???????????????η?????J?????Τ???{?? ??????I??|????????Τ?????????????ε???Y?????? ?????????????????????????100??g/mL?????s90??????? ?Τ??????????????400??g/mL?????s75??????????Q?? ???^?????γ??????????Х?????????????s200??g/mL ???_??????J????????ζ????????400??g/mL????? ??k?F???????�?^???????????? ?????x7??9?? ??????????c?????????^?????????????????????????? ??????????????????????????????????????? ???????????????????????????????????????? ?????????????????????x??????????????N??餤?? ???????????x???????_??????????????????¤??? ??????????10??20g?????????????????????p???20?r?g ??????????L??????????? ???й5,7?? ????100�?????r?g??U?????????????????24?r?g???? ??????δ?????????`?????????Ф???????????24 ?r?g????????e??й???s90?????????????????????I???? ????????pH??????????????pH??? 5 ??δ????????? pH??6.5???80?????????????飬??Υ????????^?? ????I???????????????�?^???????????? ?? ?R????? ???????R????Y??????ο??? �?R???a?? �?????????????????????c???V??650�????g????????r?? ?С?奷??????????????`????????躦?????????? 4 ?r ?g?????k?F?????????10?r?g?????????????????? ???A?????С?奷??????????????`???????????? 7 ?? ????????Υ???????????10?????????????J?????????? ?? ?a???B % of ?? ???????? ?????? 5,6?? 100 ????????????????100�?????r?g??U????????H????? ?? ?? 80 ???????a???B??????`???????¤Τ???????? ?? ?? ?? 60 �/L ?? ?? 10000 ?? 40 ?` ?? 20 1000 ?? ?????????????n??4 ?? ? 0 1 2 3 4 5 6 7 8 ?? 100 0 2 4 6 8 10 24 Days ?? ?? Hours ????????? 10 ??????????? �?????????????????????c???V??325�?????Z????? ???????? ?????????????С????????????????????k?F???????? ????????????Θ?????n??6 10 1 2 3 4 5 67 89 10 11 12 13 hr ??15??????ADP???????????????С?????????? ?????r?g ???K???????Х??????????B2??TXB2???ε??¤??J??? ?? 11?????????????J?????????? �?R?????? 7,12??18?? �?????????????????????????????????????????????? 75??1,500�/?????????????????^??Y??????????? ?????k?????????????????????????¤??J?????? ???????????J??????????? �?????????????????????????75??325�/???????? ?????????^??Y???????????????k?????×???аk???? ??????????????????????¤??J???????????????? ?J??????????? �???????????????????????75??1,500�/???????? ?????????^??Y???????????????k?????×???аk???? ??????????????????????¤??J???????????????? ?J??????????? �??^??×????k????TIA????×??????λ??????×??????`?? ????????????????????30??1,500�/???????????? ?????^??Y???????????^??×????k???k?????×???? ?k?????????????????????¤??J???????????????? ?J??????????? �????}?Х?????g??CABG??????U??U?????}?γ??g??PTCA?? ????????????????50??1,500�/??????????????? ???^??Y??????????????????????]???k????????? ????k????????????¤??J?????????????????J???? ??????? �???鲡??????????????????????П????g???30??50� /kg/??????????????????????????????u??????????? ?????????g?????????x?k??????????? 5 �/kg/?????? ??????Y?????????????}?????k?????????????????? ?J???????? ???�??�?Υ?????????R????????????餫?????????v????J ???????????K????к??????k?F???X?p????????????? ?μ?????????????ε???????????75??350�/???????X????? ????7???? ?? ??????? ?V???? 100� PTP??? 500?V??10?V??50????700?V??14?V??50?? 1,000?V??10?V??100?? ?Х?????500?V ?? ??????? 1??Ryan, T. J. et al.??J. Am. Coll. Cardiol., 28??5??, 1328??1996?? 2?????????a????????a??????????No. 151??1998?? 3??Schauerte???Х??????a??????Y???1998?? 4??Sim, S. M. et al.??Br. J. Clin. Pharmac., 32, 17??1991?? 5?????????????Х??????a??????Y???1999?? 6??Degen, J. et al.???Х??????a??????Y???1994?? 7??Federal Register, 63??205??, 56802??October 23, 1998?? 8??Wilson, J. T. et al.??Clin. Pharmacol. Ther., 23, 635??1978?? 9??Pu??tter, J.??International symposium on present state of acetylsalicylic acid in research and therapeutic application, p49??1982?? 10??Ali, M. et al.??Stroke, 11, ??1980?? 11??Jimenez, A. H. et al.??Am. J. Cardiol., 69, 258??1992?? 12??Moerloose, Ph. de. et al.??Med. Et Hyg., 49, 82??1991?? 13??Born, G.V. R.??Z. Kardiol., 79, 147??1990?? 14??Silagy, C.??Drugs ?? Aging, 3, 301??1993?? 15??Patrono, C.??New Engl. J. Med., 330, 1287??1994?? 16??Lloyd, J. et al.??Aust. Prescriber 19, 79??1996?? 17??Sato, N. et al.??Pediatr. Int., 41, ??1999?? 18????????????????С????????j?I??87, 2486??1983?? 19??Lecomte, M. et al.??J. Biol. Chem., 269, 13207??1994?? 20??Gordon, J. L. et al.??Brit. J. Pharmac., 64, 481??1978?? 21?????????・???????a??? ??10?棨?V??????, 27??, p872 ??2003?? ?? ????????? ??????????d???????Y?????????????????????¤????? ?? ?a???a?? 19,20?? - ?Х??????a????????・??????????????`????? ??????????????????????????????`??1??COX 1?????躦?????? ??л??Υ?????????????????????????????A2??TXA2?? ????530-0001 ?????б???÷??????4?? 9?? ?κ????躦?????С?????????????????????С???????? ?? ?Х????????????a??Τ???????碌?? COX-1?躦???????С?夬???????????????????????? ?Х??????a????????・????????? � 0120 -106-398 ???????????????M?????COX-1????????Ф????? ????????????????PGI2??????躦????????????^????? ????????????????x??????????????COX-1???躦?????? ?С????????????????Ф??????????????Τ??????????????? ???????????????????? 21?? ?????Τ???? ?? ????????v????????????? ??????? CO2H O O CH3 ???????????????Aspirin?? ???????2-Acetoxybenzoic acid ???????C9H8O4 ????????180.16 ??????s136?? ??????????????νY??????????????????????????鷺 ??????ζ?????? ?????????Ω`??95????????????????????????? ?????`???????????????????????????? ??????????????????????????????? ????? ?????????????Ф???????????????????? ????????? ?? ?? 6 ?? |
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wangluo335: 金币+5, ★有帮助, 审评资料已经有了，想要制剂专利，谢谢 2017-04-17 08:32:04
wangluo335: 金币+5, ★有帮助, 审评资料已经有了，想要制剂专利，谢谢 2017-04-17 08:32:04
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