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Yufeng Liu, Jingjing Zhong, Ling Lin, Juanjuan Liu, Yiguang Wang, Weiqing He, Zhaoyong Yang*, New C-19 Modified Geldanamycin Derivatives: Synthesis, Antitumor Activities and Physical Properties Study. J. Asian Nat. Prod. Res., 2016，18（8）：752-764 请帮忙查询该文是否已被SCI收录，谢谢！ |
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https://apps.webofknowledge.com/ ... age=1&doc=1 New C-19-modified geldanamycin derivatives: synthesis, antitumor activities, and physical properties study 作者:Liu, YF (Liu, Yu-Feng)[ 1,2,3 ] ; Zhong, JJ (Zhong, Jing-Jing)[ 1,2 ] ; Lin, L (Lin, Ling)[ 1,2 ] ; Liu, JJ (Liu, Juan-Juan)[ 1,2 ] ; Wang, YG (Wang, Yi-Guang)[ 1,2 ] ; He, WQ (He, Wei-Qing)[ 1,2 ] ; Yang, ZY (Yang, Zhao-Yong)[ 1,2 ] JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 卷: 18 期: 8 页: 752-764 DOI: 10.1080/10286020.2016.1160896 出版年: 2016 查看期刊信息 JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 出版商 TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND ISSN: 1028-6020 eISSN: 1477-2213 研究领域 Plant Sciences Chemistry Pharmacology & Pharmacy 摘要 Thiazinogeldanamycin (2) was identified from Streptomyces hygroscopicus 17997 at the late stage of the fermentation. The pH was firstly proposed as an important factor in the biosynthesis of it. It was verified that 2 was produced by direct chemical reactions between geldanamycin (1, GDM) and cysteine or aminoethanethiol hydrochloride at pH>7 in vitro. The proposed synthesis pathway for compound 2 was also discussed. Eleven new C-19-modified GDM derivatives, including five stable hydroquinone form derivatives, were synthesized, most of which exhibited desirable properties such as lower cytotoxicity, increased water solubility, and potent antitumor activity. Especially, compounds 5 and 8 showed antitumor activities against HepG2 cell with IC50 values of 2.97-6.61M, lower cytotoxicity and at least 15-fold higher water solubility compared with 1 in pH 7.0 phosphate buffer. 关键词 作者关键词:C-19-modified geldanamycin derivatives; synthesis; antitumor activity; stability; water solubility KeyWords Plus:STREPTOMYCES-HYGROSCOPICUS 17997; SHOCK-PROTEIN 90; BIOLOGICAL EVALUATION; IN-VITRO; HSP90; INHIBITORS; IDENTIFICATION; ANALOGS 作者信息 通讯作者地址: He, WQ; Yang, ZY (通讯作者) Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China. 增强组织信息的名称 Chinese Academy of Medical Sciences - Peking Union Medical College Institute of Medicinal Biotechnology - CAMS 通讯作者地址: He, WQ; Yang, ZY (通讯作者) Peking Union Med Coll, Beijing 100050, Peoples R China. 增强组织信息的名称 Chinese Academy of Medical Sciences - Peking Union Medical College 地址: [ 1 ] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China 增强组织信息的名称 Chinese Academy of Medical Sciences - Peking Union Medical College Institute of Medicinal Biotechnology - CAMS [ 2 ] Peking Union Med Coll, Beijing 100050, Peoples R China 增强组织信息的名称 Chinese Academy of Medical Sciences - Peking Union Medical College [ 3 ] Jining Med Univ, Dept Pharm, Jining 272067, Peoples R China 增强组织信息的名称 Jining Medical University 电子邮件地址:Heweiqing@imb.pumc.edu.cn; zhaoyongy@163.com 基金资助致谢 基金资助机构 授权号 Natural Science Foundation of China 81172965 81172972 81261120417 PUMC Youth Foundation 3332015166 查看基金资助信息关闭基金资助信息 This work was supported by the financial support from Natural Science Foundation of China [grant number 81172965], [grant number 81172972], [grant number 81261120417]; PUMC Youth Foundation [grant number 3332015166]. 出版商 TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND 类别 / 分类 研究方向  lant Sciences; Chemistry; Pharmacology & PharmacyWeb of Science 类别 lant Sciences; Chemistry, Applied; Chemistry, Medicinal; Pharmacology & Pharmacy文献信息 文献类型:Article 语种:English 入藏号: WOS:000379739300006 PubMed ID: 26988280 ISSN: 1028-6020 eISSN: 1477-2213 其他信息 IDS 号: DR2MT Web of Science 核心合集中的 "引用的参考文献": 21 Web of Science 核心合集中的 "被引频次": 0 JCR® 类别 JCR 分区 CHEMISTRY, APPLIED Q3 CHEMISTRY, MEDICINAL Q4 PHARMACOLOGY & PHARMACY Q4 PLANT SCIENCES Q3 数据来自第 2015 版 Journal Citation Reports® |
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