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The naming of Extend-Release Preparations in EU
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Regarding the extended-release preparations, here are definitions of the terms. On the y-axis(vertical) is the amount of active substance absorbed. On the x-axis(horizontal) is time. a: Normal tablet. Immediate action. b: Delayed-release. As you can see the beginning of the absorption is delayed (sometimes by coating the tablet with a gastric resistant layer). This may be because the tablet is supposed to be absorbed from the small intestine and the additional time is needed do it may pass through the stomach(so substances are sensitive to low pH and may be inactivated by gastric acids). c, d, e: Repeat-action preparation. The active substance is placed in layers within a tablet so that it is released in bursts a couple of times depending on the amounts of layers. f: Prolonged release or sustained release. I believe that those two terms are the same. The substance is released more slowly for a longer period of time. As you may notice amount of active substance released decreases with time.(this is a most common type and I believe that is the same as the Chinese sustained-release) g: Those are mixed tablets rarely used and I am not sure how are they called. h: Controlled-release. It is also called therapeutic systems. It is most modern and innovative tablet(laser boring tablet). As you may notice the amount of active substance released is constant in time) Apart from those terms there is still modified-release that I think is the term for all of those except above except a(Normal tablet). Any tablet where the release of the active substance has been changed or modified in any way. Also the term extended release is not very accurate as it can be related to many of the above terms. |
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