| 查看: 1468 | 回复: 37 | |||
| 【奖励】 本帖被评价37次，作者alanguo增加金币 29.2 个 | |||
[资源]
《Epigenetic Targets in Drug Discovery》
|
|||
|
Preface. A Personal Foreword. Part One General Aspects and Methodologies. 1 New Frontiers in Epigenetic Modifications (Adam L. Garske and John M. Denu). 1.1 Introduction. 1.2 DNA Methylation. 1.3 Histone Modifications and the Histone Code Hypothesis. 1.4 Origins of Specificity in Histone Binding Proteins/Modifying Enzymes. 1.5 Histone Modification Cross-talk. 1.6 Inhibitors of DNMTs and HDACs. 1.7 Conclusions. References. 2 Structural Biology of Epigenetic Targets (Christophe Romier, Jean-Marie Wurtz, Jean-Paul Renaud, and Jean Cavarelli). 2.1 Introduction. 2.2 Histone Acetyltransferases. 2.3 Histone Deacetylases. 2.4 Sirtuins. 2.5 Histone Methylation Enzymes. 2.6 Histone Demethylases. 2.7 DNA Methyltransferases. 2.8 Concluding Remarks: the Challenge of Structural Studies of Epigenetic Targets. References. 3 Computer- and Structure-Based Lead Identification for Epigenetic Targets (Ralf Heinke, Urszula Uciechowska, and Wolfgang Sippl). 3.1 Introduction. 3.2 Computer-Based Methods in Drug Discovery. 3.3 DNA Methyltransferases. 3.4 Histone Deacetylases. 3.5 Histone Acetyltransferases. 3.6 Histone Methyltransferases. 3.7 Histone Demethylases. 3.8 Summary. References. 4 Histone Modification Analysis Using Mass Spectrometry (Ana Villar-Garea and Axel Imhof). 4.1 Introduction. 4.2 Histone Molecules. 4.3 Capillary Electrophoresis. 4.4 Reversed Phase Chromatography. 4.5 Mass Spectrometry. References. 5 In Vitro Assays for Histone-Modifying Enzymes (Alexander-Thomas Hauser and Manfred Jung). 5.1 Introduction. 5.2 Screening Hierarchy. 5.3 General Principles of Screening for Histone-Modifying Enzymes. 5.4 Histone Deacetylases. 5.5 Histone Acetyltransferases. 5.6 Histone Methyltransferases. 5.7 Histone Demethylases. 5.8 Conclusion. References. 6 Epigenetic Targets in Drug Discovery: Cell-Based Assays for HDAC Inhibitor Hit Validation (Mira Jung, Kwon-Jeong Yong, Alfredo Velena, and Sung Lee). 6.1 Introduction. 6.2 In Vitro Assays for HDAC Inhibitors. 6.3 Cell-Based Assays. 6.4 Biological Function-Based Assays. 6.5 HDAC Isoform Functional Assays. 6.6 Anticancer Activity. 6.7 Perspective. References. 7 Chromatin Immunoprecipitation ChIP: Wet Lab Meets In Silico (Martin Seifert and Robert Schneider). 7.1 Background and Overview. 7.1.1 Chromatin and DNA Organization. 7.1.2 Chromatin Immunoprecipitation as a Powerful Method to Study Chromatin. 7.2 The Basic Principle of ChIP. 7.3 Different Variations of ChIP. 7.4 Analysis of ChIP Data. 7.5 Data Analysis Examples. 7.6 The Future of ChIP. References. Part Two Epigenetic Target Classes and Inhibitor Development. 8 DNA Methyltransferase Inhibitors (Wolfgang Sippl and Manfred Jung). 8.1 Introduction. 8.2 DNA Methylation. 8.3 DNA Methyltransferases. 8.4 Biochemical Mechanism of DNA Methylation. 8.5 Physiological Role of DNA Methylation. 8.6 DNA Methylation and Disease. 8.7 DNMT Inhibitors. 8.8 Therapeutic Applications of DNMT Inhibitors. 8.9 Conclusion. References. 9 Histone Deacetylase Inhibitors (Philip Jones). 9.1 Introduction. 9.2 Mechanism and X-Ray Crystal Structure. 9.3 Histone Deacetylase Inhibitors. 9.4 Conclusions. References. 10 NAD-Dependent Deacetylases as Therapeutic Targets (Hongzhe Li, Julian Simon, and Antonio Bedalov). 10.1 Historical Perspective and Functions of Sir2 in Yeast. 10.2 Sirtuin Enzymatic Activity and its Modulation by Endogenous Molecules. 10.3 Small Molecule Inhibitors of Sirtuins. 10.4 Small Molecule Activators of Sirtuins. 10.5 SIRT1 as a Therapeutic Target in Metabolic Syndrome and Type 2 Diabetes. 10.6 Neurological Diseases. 10.7 Conclusion. References. 11 Inhibitors of Histone Acetyltransferases: Discovery and Biomedical Perspectives (Margarete von Wantoch Rekowski and Athanassios Giannis). 11.1 Introduction. 11.2 HAT Inhibitors. 11.3 Summary. References. 12 Histone Methyltransferases as Novel Drug Targets (Manfred Jung). 12.1 Introduction. 12.2 Protein Methylation. 12.3 Histone Demethylation. 12.4 Histone Methyltransferases. 12.5 Histone Methyltransferase Inhibitors. 12.6 Concluding Remarks. References. 13 Histone Demethylases (Rasmus P. Clausen, Marianne T. Pedersen, and Kristian Helin). 13.1 Introduction. 13.2 Chromatin. 13.3 Histone Methylation and Demethylation. 13.4 Histone Demethylases. 13.5 LSD1/KDM1. 13.5.1 Inhibitors of LSD1. 13.6 JmjC Domain-Containing Demethylases. 13.7 Summary. References. Index. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : Epigenetic_Targets_in_Drug_Discovery_(Methods_and_Principles_in_Medicinal_Chemistry).pdf
2016-08-02 21:59:39, 4.03 M
» 收录本帖的淘帖专辑推荐
 药物合成 |
» 猜你喜欢
基于AI智能算法的装备结构可靠性分析与优化设计技术
已经有0人回复
-
求助求助
已经有0人回复
-
药物学论文润色/翻译怎么收费?
已经有97人回复
-
农业资源与环境、智慧农业专业本科生毕业论文课题选题求助
已经有1人回复
-
人工智能赋能聚合物及复合材料模型应用与实践
已经有0人回复
-
各国和国际组织现行药典注射用水质量标准
已经有0人回复
-
求助用微谱数据库查询
已经有0人回复
-
计算化学与人工智能驱动的MOFs性能预测与筛选技术
已经有0人回复
-
研三实验求指导
已经有0人回复
-
金属材料多尺度计算模拟技术与应用：微观机理到宏观性能的集成工作
已经有0人回复
-
江西科技师范大学微生物天然药物老师介绍
已经有23人回复
38楼2019-11-25 04:03:43
简单回复
pingshan2楼
2016-08-03 06:50
回复
五星好评 顶一下，感谢分享！
work0373楼
2016-08-03 08:51
回复
五星好评 顶一下，感谢分享！
wslld4楼
2016-08-03 11:05
回复
五星好评 顶一下，感谢分享！
pumcnsy5楼
2016-08-03 23:00
回复
五星好评 顶一下，感谢分享！
henryyip6楼
2016-08-04 07:48
回复
五星好评 顶一下，感谢分享！
2016-08-04 09:10
回复
五星好评 顶一下，感谢分享！
2016-08-04 14:18
回复
五星好评 顶一下，感谢分享！
2016-08-04 15:48
回复
五星好评 顶一下，感谢分享！
nihaoweiming10楼
2016-08-04 18:48
回复
五星好评 顶一下，感谢分享！
wang36911楼
2016-08-04 23:05
回复
五星好评 顶一下，感谢分享！
zhchzhsh207612楼
2016-08-04 23:10
回复
五星好评 顶一下，感谢分享！
ochotona13楼
2016-08-05 04:10
回复
五星好评 顶一下，感谢分享！
小明子014楼
2016-08-05 12:41
回复
五星好评 顶一下，感谢分享！
owenyx_198115楼
2016-08-05 15:15
回复
五星好评 顶一下，感谢分享！
msd2phd16楼
2016-08-06 09:05
回复
五星好评 顶一下，感谢分享！
wujian883317楼
2016-08-06 11:20
回复
五星好评 顶一下，感谢分享！
wutravel18楼
2016-08-07 08:40
回复
五星好评 顶一下，感谢分享！
xwj00719楼
2016-08-08 14:23
回复
五星好评 顶一下，感谢分享！
惟精惟一20楼
2016-08-21 13:04
回复
五星好评 顶一下，感谢分享！
lvbeike21楼
2016-09-04 11:15
回复
五星好评 顶一下，感谢分享！
Aphgo22楼
2016-11-06 16:42
回复
五星好评 顶一下，感谢分享！
macore23楼
2016-11-21 08:36
回复
五星好评 顶一下，感谢分享！
晕月山江24楼
2016-12-03 16:50
回复
五星好评 顶一下，感谢分享！
geju25楼
2017-02-03 21:41
回复
五星好评 顶一下，感谢分享！
wangzgsh26楼
2017-02-04 08:41
回复
五星好评 顶一下，感谢分享！
abc7527楼
2017-04-03 12:22
回复
五星好评 顶一下，感谢分享！
qjgmedchem28楼
2017-04-04 11:39
回复
五星好评 顶一下，感谢分享！
tianhai888129楼
2017-07-24 16:20
回复
五星好评 顶一下，感谢分享！
lvyong62530楼
2017-10-20 12:20
回复
一般 顶一下，感谢分享！
ronghua432131楼
2017-10-20 20:04
回复
五星好评 顶一下，感谢分享！
ckenke00832楼
2017-10-20 22:59
回复
五星好评 顶一下，感谢分享！
snow92733楼
2018-12-11 10:19
回复
五星好评 顶一下，感谢分享！
ansuan200834楼
2018-12-13 10:13
回复
五星好评 顶一下，感谢分享！
an020835楼
2019-06-12 20:04
回复
五星好评 顶一下，感谢分享！
那个夏天秋天36楼
2019-10-28 13:53
回复
五星好评 顶一下，感谢分享！
kingwang137楼
2019-11-24 23:43
回复
五星好评 谢谢分享！
