| 查看: 280 | 回复: 0 | |||
[交流]
固体药物溶解热的表征
|
| Solid pharmaceuticals are often milled, dried, compressed or otherwise manipulated during production of the final tablet or capsule format. Since any of these steps can change the solid state properties of the drug, each step must be carefully characterized and understood in order to ensure that the overall formulation process is robust and generates a reproducible and stable final product. For example, milling is often used to reduce the particle size of a drug in order to improve solubility, flow characteristics or compressibility. However, milling can also affect critical physical properties such as formation of an amorphous fraction, metastable crystalline polymorphs, or an unwanted hydrate fraction. The formation of any of these phases can impact both bioavailability and chemical stability of the drug. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : 固体药物溶解热的表征.pdf
2016-07-04 16:25:28, 358.02 K
» 猜你喜欢
求各位大神看下
已经有17人回复
-
好消息？这个有何含义？？？
已经有10人回复
-
咨询面上基金
已经有4人回复
-
8月时间戳变的，举个手。玩一下，释放压力
已经有10人回复
-
【2027博士申请】纳米药物递送方向
已经有4人回复
-
面上再次挂了，太难了，躺也躺不了，倦也卷不过，小学校之殇！
已经有29人回复
-
UV压敏胶开发
已经有7人回复
-
有没有H口的？有收到消息的吗？
已经有3人回复
-
十年后又回来了，论文投稿求助
已经有3人回复
-
纯娱乐，不喜欢勿喷
已经有10人回复