| 查看: 241 | 回复: 0 | |||
[交流]
微量热法在固体药物的物理性质变化表征中的应用
|
|
Particle size reduction (grinding, micronization) is a common process when dealing with powder technology, as is the case in the pharmaceutical, chemical and food industries. When crystalline compounds are exposed to such mechanical stress, disturbances occur in their structure due to the creation of amorphous regions. These regions exhibit physical and/or chemical properties quite different to those areas remaining crystalline. Such a change in the degre1e of crystallinity may affect the mechanical (e.g. flow properties), the physical (e.g. solubility), chemical (Ie.g. stability) and pharmacological (e.g. bioavailability) properties of the powder. Moreover, further pharmaceutical processing of the powder depends strongly on its degree of amorphicity. Even if the sample is amorphous only Ito a small extent, this can be of critical importance since these regions will mainly be present on the surfaces of the particles. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : 微量热法在固体药物的物理性质变化表征中的应用.pdf
2016-07-01 15:29:38, 569.34 K
» 猜你喜欢
有多少人是今天查系统知道结果的？
已经有19人回复
-
哪位高人中了，把查询到的截图贴出来让我看看，让我长长见识
已经有7人回复
-
面上意见出来了
已经有23人回复
-
能否申诉？
已经有8人回复
-
梦想
已经有5人回复
-
中青基了要发朋友圈吗？
已经有7人回复
-
29号明天会评吗
已经有4人回复
-
国社科又开始会评了，不知道这次命运如何
已经有10人回复
-
基金不中，共勉
已经有12人回复
-
为什么到现在没收到通知？
已经有5人回复
投票:
30