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微量热法在固体药物的物理性质变化表征中的应用
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Particle size reduction (grinding, micronization) is a common process when dealing with powder technology, as is the case in the pharmaceutical, chemical and food industries. When crystalline compounds are exposed to such mechanical stress, disturbances occur in their structure due to the creation of amorphous regions. These regions exhibit physical and/or chemical properties quite different to those areas remaining crystalline. Such a change in the degre1e of crystallinity may affect the mechanical (e.g. flow properties), the physical (e.g. solubility), chemical (Ie.g. stability) and pharmacological (e.g. bioavailability) properties of the powder. Moreover, further pharmaceutical processing of the powder depends strongly on its degree of amorphicity. Even if the sample is amorphous only Ito a small extent, this can be of critical importance since these regions will mainly be present on the surfaces of the particles. |
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2016-07-01 15:29:38, 569.34 K
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