| 查看: 229 | 回复: 0 | |||
[交流]
微量热法在固体药物的物理性质变化表征中的应用
|
|
Particle size reduction (grinding, micronization) is a common process when dealing with powder technology, as is the case in the pharmaceutical, chemical and food industries. When crystalline compounds are exposed to such mechanical stress, disturbances occur in their structure due to the creation of amorphous regions. These regions exhibit physical and/or chemical properties quite different to those areas remaining crystalline. Such a change in the degre1e of crystallinity may affect the mechanical (e.g. flow properties), the physical (e.g. solubility), chemical (Ie.g. stability) and pharmacological (e.g. bioavailability) properties of the powder. Moreover, further pharmaceutical processing of the powder depends strongly on its degree of amorphicity. Even if the sample is amorphous only Ito a small extent, this can be of critical importance since these regions will mainly be present on the surfaces of the particles. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : 微量热法在固体药物的物理性质变化表征中的应用.pdf
2016-07-01 15:29:38, 569.34 K
» 猜你喜欢
时间戳又变了
已经有6人回复
-
2026年面上项目中了，2A+B, 会评顺利通过
已经有5人回复
-
售T0P一区SCI文章，我:8O5.51.O.54,科目齐全,可＋急
已经有4人回复
-
售T0P一区SCI文章，我:8O5.51.O.54,科目齐全,可＋急
已经有4人回复
-
大家好，校样时候的紧急求助，请各位帮帮忙了
已经有7人回复
-
昨日死，今日生
已经有7人回复
-
售T0P一区SCI文章，我:8O5.51.O.54,科目齐全,可＋急
已经有7人回复
-
植酸TLC薄层色谱爬板
已经有6人回复
-
单宁酸
已经有3人回复
-
双环［1.1.0］丁烷（bcb）合成
已经有6人回复