| 查看: 240 | 回复: 0 | |||
[交流]
微量热法在固体药物的物理性质变化表征中的应用
|
|
Particle size reduction (grinding, micronization) is a common process when dealing with powder technology, as is the case in the pharmaceutical, chemical and food industries. When crystalline compounds are exposed to such mechanical stress, disturbances occur in their structure due to the creation of amorphous regions. These regions exhibit physical and/or chemical properties quite different to those areas remaining crystalline. Such a change in the degre1e of crystallinity may affect the mechanical (e.g. flow properties), the physical (e.g. solubility), chemical (Ie.g. stability) and pharmacological (e.g. bioavailability) properties of the powder. Moreover, further pharmaceutical processing of the powder depends strongly on its degree of amorphicity. Even if the sample is amorphous only Ito a small extent, this can be of critical importance since these regions will mainly be present on the surfaces of the particles. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : 微量热法在固体药物的物理性质变化表征中的应用.pdf
2016-07-01 15:29:38, 569.34 K
» 猜你喜欢
售SCI文章，我:8O.5.5.1O.54,科目全,可十急
已经有3人回复
-
售SCI一区文章，我:8.O.55.1.O.54,科目齐全,可伽急
已经有3人回复
-
我就是申请一个面上项目而已，这评审意见是按照杰青的条件评的吧？
已经有3人回复
-
有多少人是今天查系统知道结果的？
已经有18人回复
-
国自然评审意见
已经有15人回复
-
为什么资助数各大高校都创新高，自己申请怎么就这么难
已经有13人回复
-
国自然面上复盘~欢迎讨论
已经有14人回复
-
系统查不到
已经有11人回复
-
有没有仍没收到信息的
已经有3人回复
-
导师吐槽：我怎么摊上了这么个极品研究生！
已经有8人回复
