| 查看: 616 | 回复: 0 | |||
gy_xmc2015铜虫 (小有名气)
|
[交流]
文章推荐｜Antonios G. Mikos综述：他汀类药物在骨骼再生领域的新应用
|
|
http://nsr.oxfordjournals.org/content/2/1/85.full ABSTRACT The use of statins for bone regeneration is a promising and growing area of research. Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl, the rate-limiting enzyme of the mevalonate pathway. Because the mevalonate pathway is responsible for the synthesis of a wide variety of important biochemical molecules, including cholesterol and other isoprenoids, the effects of statins are pleiotropic. In particular, statins can greatly affect the process of bone turnover and regeneration via effects on important cell types, including mesenchymal stem cells, osteoblasts, endothelial cells, and osteoclasts. Statins have also been shown to have anti-inflammatory and antimicrobial properties that may be useful since infection can derail normal bone healing. This review will explore the pleiotropic effects of statins, discuss the current use of statins for bone regeneration, particularly with regard to biomaterials-based controlled delivery, and offer perspectives on the challenges and future directions of this emerging area of bone tissue engineering. Keywords: tissue engineering, osteogenesis, statin, HMG-CoA reductase, local delivery |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : Natl_Sci_Rev-2015-Shah-85-99.pdf
2016-05-25 09:53:08, 755.69 K
» 猜你喜欢
[国际期刊]生物材料BM期刊：青年编委招募中，也欢迎投稿交流
已经有9人回复
-
大家帮忙点点链接哈，推广下工作
已经有75人回复
-
生物力学与组织工程学论文润色/翻译怎么收费?
已经有258人回复
-
2026年底前免APC！这些Scopus收录的英文国际期刊在征稿
已经有8人回复
-
【Scoupus英文期刊】Biofunctional Materials生物功能性材料期刊长期征稿中
已经有9人回复
-
间充质干细胞（MSC）用化学成分限定培养基鉴定方法
已经有0人回复
-
多本 Scopus 收录国际英文 OA 期刊长期收稿~全免 APC！
已经有10人回复
-
诚邀生物医用材料领域学者加入Biofunctional Materials青年编委（Scopus收录）
已经有11人回复