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| SPARCL1 suppresses metastasis in prostate cancer |
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SPARCL1 suppresses metastasis in prostate cancer 作者:Xiang, YZ (Xiang, Yuzhu)[ 1,2 ] ; Qiu, QC (Qiu, Qingchao)[ 1,10,11 ] ; Jiang, M (Jiang, Ming)[ 3,4,12 ] ; Jin, RJ (Jin, Renjie)[ 3,4 ] ; Lehmann, BD (Lehmann, Brian D.)[ 6 ] ; Strand, DW (Strand, Douglas W.)[ 3,4 ] ; Jovanovic, B (Jovanovic, Bojana)[ 7 ] ; DeGraff, DJ (DeGraff, David J.)[ 3,4 ] ; Zheng, Y (Zheng, Yi)[ 1,2 ] ; Yousif, DA (Yousif, Dina A.)[ 1 ] ; Simmons, CQ (Simmons, Christine Q.)[ 1 ] ; Case, TC (Case, Thomas C.)[ 3,4 ] ; Yi, J (Yi, Jia)[ 1 ] ; Cates, JM (Cates, Justin M.)[ 8 ] ; Virostko, J (Virostko, John)[ 9 ] ; He, XS (He, Xiusheng)[ 10,11 ] ; Jin, XB (Jin, Xunbo)[ 2 ] ; Hayward, SW (Hayward, Simon W.)[ 3,4,7 ] ; Matusik, RJ (Matusik, Robert J.)[ 3,4,7 ] ; George, AL (George, Alfred L., Jr.)[ 1,5 ] ; Yi, YJ (Yi, Yajun)[ 1,5 ] 更多内容更少内容 隐藏 ResearcherID 和 ORCID查看 ResearcherID 和 ORCID 作者 ResearcherID ORCID 号 Cates, Justin D-5927-2014 https://orcid.org/0000-0002-7336-5196 Strand, Douglas https://orcid.org/0000-0002-0746-927X MOLECULAR ONCOLOGY 卷: 7 期: 6 页: 1019-1030 DOI: 10.1016/j.molonc.2013.07.008 出版年: DEC 2013 查看期刊信息 MOLECULAR ONCOLOGY 出版商 ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND ISSN: 1574-7891 eISSN: 1878-0261 研究领域 Oncology 摘要 Purpose: Metastasis, the main cause of death from cancer, remains poorly understood at the molecular level. Experimental design: Based on a pattern of reduced expression in human prostate cancer tissues and tumor cell lines, a candidate suppressor gene (SPARCL1) was identified. We used in vitro approaches to determine whether overexpression of SPARCL1 affects cell growth, migration, and invasiveness. We then employed xenograft mouse models to analyze the impact of SPARCL1 on prostate cancer cell growth and metastasis in vivo. Results: SPARCL1 expression did not inhibit tumor cell proliferation in vitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness in vitro and tumor metastatic growth in vivo, conferring improved survival in xenograft mouse models. Conclusions: We present the first in vivo data suggesting that SPARCL1 suppresses metastasis of prostate cancer. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. 关键词 作者关键词  rostate cancer; Gene expression signature; Meta-analysis; Metastasis; SPARCL1 function in vivo KeyWords Plus:EXTRACELLULAR-MATRIX PROTEIN; MESENCHYMAL TRANSITION; MATRICELLULAR PROTEIN; SECRETED-PROTEIN; BONE METASTASIS; TUMOR-CELLS; EXPRESSION; HEVIN; STATISTICS; CARCINOMA 作者信息 通讯作者地址: Yi, YJ (通讯作者) Vanderbilt Univ, Div Med Genet, 536A Light Hall,2215 Garland Ave, Nashville, TN 37232 USA. 增强组织信息的名称 Vanderbilt University 地址: [ 1 ] Vanderbilt Univ, Dept Med, Nashville, TN 37232 USA 增强组织信息的名称 Vanderbilt University [ 2 ] Shandong Univ, Prov Hosp, Minimally Invas Urol Ctr, Jinan 250021, Peoples R China 增强组织信息的名称 Shandong University [ 3 ] Vanderbilt Univ, Vanderbilt Prostate Canc Ctr, Nashville, TN 37232 USA 增强组织信息的名称 Vanderbilt University [ 4 ] Vanderbilt Univ, Dept Urol Surg, Nashville, TN 37232 USA 增强组织信息的名称 Vanderbilt University [ 5 ] Vanderbilt Univ, Inst Integrat Gen, Nashville, TN 37232 USA 增强组织信息的名称 Vanderbilt University [ 6 ] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA 增强组织信息的名称 Vanderbilt University [ 7 ] Vanderbilt Univ, Dept Canc Biol, Nashville, TN 37232 USA 增强组织信息的名称 Vanderbilt University [ 8 ] Vanderbilt Univ, Dept Pathol Microbiol & Immunol, Nashville, TN 37232 USA 增强组织信息的名称 Vanderbilt University [ 9 ] Vanderbilt Univ, Dept Radiol & Radiol Sci, Nashville, TN 37232 USA 增强组织信息的名称 Vanderbilt University [ 10 ] Univ South China, Canc Res Inst, Hengyang 421001, Peoples R China 增强组织信息的名称 University of South China [ 11 ] Univ South China, Human Morphol Ctr, Hengyang 421001, Peoples R China 增强组织信息的名称 University of South China [ 12 ] Nantong Univ, Med Res Ctr, Sch Med, Lab Nucl Receptors & Canc Res, Nantong, Peoples R China 增强组织信息的名称 Nantong University 电子邮件地址:yuzhuxiang@gmail.com; qingchao.qiu@vanderbilt.edu; ming.jiang.1@ntu.edu.cn; re-njie.jin@Vanderbilt.edu; brian.d.lehmann@Vanderbilt.edu; doug.strand@Vanderbilt.edu; bojana.jo-vanovic@Vanderbilt.edu; david.degraff@Vanderbilt.edu; milozhengyi@gmail.com; dina.a.yousif@Vanderbilt.edu; christine.simmons@Vanderbilt.Edu; tom.case@Vanderbilt.edu; jyi5@uthsc.edu; justin.m.cates@Vanderbilt.edu; jack.virostko@vanderbilt.edu; hexiusheng@hotmail.com; jin-xunbo@163.com; simon.hayward@vanderbilt.edu; robert.matusik@vanderbilt.edu; al.george@vanderbilt.edu; yajun.yi@vanderbilt.edu 基金资助致谢 基金资助机构 授权号 Howard Temin Award from the National Cancer Institute at the National Institutes of Health CA114033 American Cancer Society-Institutional Research Grant IRG-58-009-51 IRG-58-009-53 Vanderbilt Clinical and Translational Science Awards (CTSA) from National Center for Research Resources (NCRR), a part of the National Institutes of Health (NIH) UL1 RR024975 CRC1838 National Cancer Institute 4R01-CA076142-14 American Cancer Society Great Lakes Division-Michigan Cancer Research Fund Postdoctoral Fellowship 查看基金资助信息关闭基金资助信息 Grant Support: This work was supported in part by a Howard Temin Award from the National Cancer Institute at the National Institutes of Health (CA114033 to YY), American Cancer Society-Institutional Research Grant (#IRG-58-009-51 and #IRG-58-009-53), and the Vanderbilt Clinical and Translational Science Awards (CTSA) UL1 RR024975 from National Center for Research Resources (NCRR), a part of the National Institutes of Health (NIH), (CRC1838 to YY), and the National Cancer Institute (4R01-CA076142-14 to RJM). DJD was supported by the American Cancer Society Great Lakes Division-Michigan Cancer Research Fund Postdoctoral Fellowship. 出版商 ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND 类别 / 分类 研究方向:Oncology Web of Science 类别:Oncology 文献信息 文献类型:Article 语种:English 入藏号: WOS:000328176400003 PubMed ID: 23916135 ISSN: 1574-7891 eISSN: 1878-0261 其他信息 IDS 号: 268NA Web of Science 核心合集中的 "引用的参考文献": 50 Web of Science 核心合集中的 "被引频次": 2 影响因子 5.331 5.669 2014 5 年 JCR® 类别 类别中的排序 JCR 分区 ONCOLOGY 28/211 Q1 数据来自第 2014 版 Journal Citation Reports® |
2楼2016-05-09 12:42:28
