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Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1βgene and prostate cancer: a systematic review and meta-analysis

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Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1 beta gene and prostate cancer: a systematic review and meta-analysis

作者:Xiang, YZ (Xiang, Y. Z.)[ 1 ] ; Jiang, SB (Jiang, S. B.)[ 1 ] ; Zhao, J (Zhao, J.)[ 2 ] ; Xiong, H (Xiong, H.)[ 1 ] ; Cui, ZL (Cui, Z. L.)[ 1 ] ; Li, GB (Li, G. B.)[ 1 ] ; Jin, XB (Jin, X. B.)[ 1 ]

GENETICS AND MOLECULAR RESEARCH

卷: 13

期: 3

页: 6582-6592

DOI: 10.4238/2014.August.28.3

出版年: 2014

查看期刊信息
摘要

Polymorphism 17q12 rs4430796 within HNF1 beta is a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the odds ratios (ORs) with corresponding 95% confidence intervals (CIs) of all currently available case-control studies located within PubMed and Embase databases up to December 2012. A total of 16 studies comprising 30 datasets that collectively involved 25,535 prostate cancer patients and 25,726 controls were ultimately included in this analysis. The meta-analysis of all the studies revealed that the rs4430796 polymorphism was significantly associated with an increased risk of prostate cancer in all contrast models (ORA vs (G) = 1.25, 95%CI = 1.21-1.30, P-OR < 0.001; ORAA vs (GG) = 1.53, 95%CI = 1.45-1.62, P-OR < 0.001; ORAG vs (GG) = 1.24, 95%CI = 1.16-1.34, P-OR < 0.001; ORAA vs (AG+GG) = 1.36, 95%CI = 1.30-1.42, P-OR < 0.001; ORAA+AG vs (GG) = 1.37, 95%CI = 1.30-1.44, P-OR < 0.001). After subgroup analyses stratified by ethnicity, however, the rs4430796 polymorphism was significantly associated with prostate cancer in both Caucasians and Asians but not in African-Americans. In conclusion, our meta-analysis identified a significant association between the 17q12 rs4430796 polymorphism and prostate cancer risk, although the degree of this association and frequency of the causative allele varied among men of different races.
关键词

作者关键词:HNF1 beta; Genetic polymorphisms; Prostate cancer; Diabetes mellitus; Meta-analysis

KeyWords Plus:GENOME-WIDE ASSOCIATION; RISK LOCI; AFRICAN-AMERICANS; VARIANTS; 17Q12; REPLICATION; STATISTICS; POPULATIONS; 8Q24
作者信息

通讯作者地址: Jin, XB (通讯作者)
[显示增强组织信息的名称] Shandong Univ, Prov Hosp, Minimally Invas Urol Ctr, Jinan 250100, Peoples R China.

地址:
[显示增强组织信息的名称] [ 1 ] Shandong Univ, Prov Hosp, Minimally Invas Urol Ctr, Jinan 250100, Peoples R China
[显示增强组织信息的名称] [ 2 ] Shandong Univ, Prov Hosp, Dept Emergency, Jinan 250100, Peoples R China

电子邮件地址:jinxunbo@163.com
基金资助致谢
基金资助机构授权号
China Scholarship Council
2009622110
National Science Fund for Distinguished Young Scholars
81202016
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出版商

FUNPEC-EDITORA, RUA FLORIANO PEIXOTO 2444, ALTO DA BOA VISTA, RIBEIRAO PRETO, SP 00000, BRAZIL
类别 / 分类

研究方向:Biochemistry & Molecular Biology; Genetics & Heredity

Web of Science 类别:Biochemistry & Molecular Biology; Genetics & Heredity
文献信息

文献类型:Article

语种:English

入藏号: WOS:000343049600023

PubMed ID: 25177939

ISSN: 1676-5680
期刊信息

Impact Factor (影响因子): Journal Citation Reports®

其他信息

IDS 号: AQ8CG

Web of Science 核心合集中的 "引用的参考文献": 36

Web of Science 核心合集中的 "被引频次": 1

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