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Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1βgene and prostate cancer: a systematic review and meta-analysis 急求，谢谢！ |
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lazy锦溪
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Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1 beta gene and prostate cancer: a systematic review and meta-analysis 作者:Xiang, YZ (Xiang, Y. Z.)[ 1 ] ; Jiang, SB (Jiang, S. B.)[ 1 ] ; Zhao, J (Zhao, J.)[ 2 ] ; Xiong, H (Xiong, H.)[ 1 ] ; Cui, ZL (Cui, Z. L.)[ 1 ] ; Li, GB (Li, G. B.)[ 1 ] ; Jin, XB (Jin, X. B.)[ 1 ] GENETICS AND MOLECULAR RESEARCH 卷: 13 期: 3 页: 6582-6592 DOI: 10.4238/2014.August.28.3 出版年: 2014 查看期刊信息 摘要 Polymorphism 17q12 rs4430796 within HNF1 beta is a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findings, therefore, we carried out a meta-analysis by pooling the odds ratios (ORs) with corresponding 95% confidence intervals (CIs) of all currently available case-control studies located within PubMed and Embase databases up to December 2012. A total of 16 studies comprising 30 datasets that collectively involved 25,535 prostate cancer patients and 25,726 controls were ultimately included in this analysis. The meta-analysis of all the studies revealed that the rs4430796 polymorphism was significantly associated with an increased risk of prostate cancer in all contrast models (ORA vs (G) = 1.25, 95%CI = 1.21-1.30, P-OR < 0.001; ORAA vs (GG) = 1.53, 95%CI = 1.45-1.62, P-OR < 0.001; ORAG vs (GG) = 1.24, 95%CI = 1.16-1.34, P-OR < 0.001; ORAA vs (AG+GG) = 1.36, 95%CI = 1.30-1.42, P-OR < 0.001; ORAA+AG vs (GG) = 1.37, 95%CI = 1.30-1.44, P-OR < 0.001). After subgroup analyses stratified by ethnicity, however, the rs4430796 polymorphism was significantly associated with prostate cancer in both Caucasians and Asians but not in African-Americans. In conclusion, our meta-analysis identified a significant association between the 17q12 rs4430796 polymorphism and prostate cancer risk, although the degree of this association and frequency of the causative allele varied among men of different races. 关键词 作者关键词:HNF1 beta; Genetic polymorphisms; Prostate cancer; Diabetes mellitus; Meta-analysis KeyWords Plus:GENOME-WIDE ASSOCIATION; RISK LOCI; AFRICAN-AMERICANS; VARIANTS; 17Q12; REPLICATION; STATISTICS; POPULATIONS; 8Q24 作者信息 通讯作者地址: Jin, XB (通讯作者) [显示增强组织信息的名称] Shandong Univ, Prov Hosp, Minimally Invas Urol Ctr, Jinan 250100, Peoples R China. 地址: [显示增强组织信息的名称] [ 1 ] Shandong Univ, Prov Hosp, Minimally Invas Urol Ctr, Jinan 250100, Peoples R China [显示增强组织信息的名称] [ 2 ] Shandong Univ, Prov Hosp, Dept Emergency, Jinan 250100, Peoples R China 电子邮件地址:jinxunbo@163.com 基金资助致谢 基金资助机构 授权号 China Scholarship Council 2009622110 National Science Fund for Distinguished Young Scholars 81202016 查看基金资助信息 出版商 FUNPEC-EDITORA, RUA FLORIANO PEIXOTO 2444, ALTO DA BOA VISTA, RIBEIRAO PRETO, SP 00000, BRAZIL 类别 / 分类 研究方向:Biochemistry & Molecular Biology; Genetics & Heredity Web of Science 类别:Biochemistry & Molecular Biology; Genetics & Heredity 文献信息 文献类型:Article 语种:English 入藏号: WOS:000343049600023 PubMed ID: 25177939 ISSN: 1676-5680 期刊信息 Impact Factor (影响因子): Journal Citation Reports® 其他信息 IDS 号: AQ8CG Web of Science 核心合集中的 "引用的参考文献": 36 Web of Science 核心合集中的 "被引频次": 1 |
2楼2016-05-09 10:30:18
lazy锦溪
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3楼2016-05-09 10:30:48
