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ccession number: 20161102095276 Title: Analysis of a Haplotype Structure in a Non-coding Region of Human Chromosome 22 Authors: Sun, Jian-Hong1 Email author sparkhonghee@foxmail.com Author affiliation: 1 Engineering College, Honghe University, Yunnan, Mengzi, China Corresponding author: Sun, Jian-Hong (sparkhonghee@foxmail.com) Source title: Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015 Abbreviated source title: Proc. - Int. Conf. Meas. Technol. Mechatronics Autom., ICMTMA Monograph title: Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015 Issue date: September 11, 2015 Publication year: 2015 Pages: 137-140 Article number: 7263531 Language: English ISBN-13: 9781467371438 Document type: Conference article (CA) Conference name: 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015 Conference date: June 13, 2015 - June 14, 2015 Conference location: Nanchang, Jiangxi, China Conference code: 118120 Sponsor: Central South University of Forest and Technology; Hunan Institute of Industry; Institute of Spatial Information Technology; Shenzhen Research Institute of Central South University Publisher: Institute of Electrical and Electronics Engineers Inc. Abstract: Haplotype structures are important in the study of human evolutionary history. These structures effectively simplify genome-wide association studies by reducing the number of mutations to be examined. Here, a haplotype block was analysed which located on 22q12.3 (Position: 34876961-34890077), a noncoding region of chromosome 22. Statistical tests suggested that the region is selectively neutral with a very low recombination rate. The genetic diversity analysis shows that the African population (AFR) has higher diversity than non-AFR populations. The results show that only 52 of 2,184 possible haplotypes are observed on this block. The haplotype distribution concentrates on 4~5 common haplotypes in non-African populations. However, the haplotypes are more evenly and more widely expressed in AFR. Due to genetic drift or sampling, these SNPs with strong LD(Linkage Disequilibrium) of this block is not observed in ASN. Results show that the strong LD structure was generated before humans left Africa. © 2015 IEEE. Number of references: 17 Main heading: Chromosomes Controlled terms: Mechanical engineering - Mechatronics Uncontrolled terms: Evolutionary history - Genome-wide association studies - Haplotype structure - Haplotypes - Linkage disequilibrium - Non-coding region - Recombination rate - Single-nucleotide polymorphisms Classification code: 461.2 Biological Materials and Tissue Engineering - 608 Mechanical Engineering, General - 731.7 Mechatronix DOI: 10.1109/ICMTMA.2015.39 Database: Compendex Compilation and indexing terms, © 2016 Elsevier Inc. |
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