±±¾©Ê¯ÓÍ»¯¹¤Ñ§Ôº2026ÄêÑо¿ÉúÕÐÉú½ÓÊÕµ÷¼Á¹«¸æ
²é¿´: 660  |  »Ø¸´: 1
±¾Ìû²úÉú 1 ¸ö ·­ÒëEPI £¬µã»÷ÕâÀï½øÐв鿴

jdy1947

½ð³æ (СÓÐÃûÆø)

[ÇóÖú] Çó·­ÒëÒ»¶ÎÕªÒª

Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to display a variety of
biological activities. Thiazole and its derivatives have attracted continuing interest to design various
novel CNS active agents. In the past few decades, thiazoles have been widely used to develop a variety of
therapeutic agents against numerous CNS targets. Thiazole containing drug molecules are currently
being used in treatment of various CNS disorders and a number of thiazole derivatives are also presently
in clinical trials. A lot of research has been carried out on thiazole and their analogues, which has proved
their efficacy to overcome several CNS disorders in rodent as well as primate models. The aim of present
review is to highlights diverse CNS activities displayed by thiazole and their derivatives. SAR of this
nucleus has also been well discussed. This review covers the recent updates present in literature and will
surely provide a greater insight for the designing and development of potent thiazole based CNS active
agents in future.

» ²ÂÄãϲ»¶

ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

Î人һÐÄÒ»Òë

¾èÖú¹ó±ö (ÖøÃûдÊÖ)


¡¾´ð°¸¡¿Ó¦Öú»ØÌû

É̼ÒÒѾ­Ö÷¶¯ÉùÃ÷´Ë»ØÌû¿ÉÄܺ¬ÓÐÐû´«ÄÚÈÝ
¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï
jdy1947: ½ð±Ò+50, ·­ÒëEPI+1, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2016-05-03 08:12:31
Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to display a variety of biological activities. Thiazole and its derivatives have attracted continuing interest to design various novel CNS active agents.
×÷ΪҽÁÆ»¯Ñ§ÁìÓòµÄÒ»ÖÖÖØÒªµÄÖ§¼Ü£¬àçßòÄÜ×÷ÓÃÓÚ¸÷ÖÖÉúÎï»î¶¯ÖС£ÈËÃÇÒ»Ö±ÔÚ³¢ÊÔ»ùÓÚàçßòºÍÆäÑÜÉúÎïÉè¼Æ¸÷ÖÖÐÂÐÍ»îÐÔ¼Á¡£

In the past few decades, thiazoles have been widely used to develop a variety of therapeutic agents against numerous CNS targets. Thiazole containing drug molecules are currently being used in treatment of various CNS disorders and a number of thiazole derivatives are also presently in clinical trials.
ÔÚ¹ýÈ¥µÄ¼¸Ê®ÄêÀàçßò±»¹ã·ºÔËÓÃÓÚ¿ª·¢¸÷ÖÖµÄÖÎÁƼÁ£¬ÒÔÖÎÁÆÖÎÁÆÖÐÊàÉñ¾­ÏµÍ³¼²²¡¡£ÏÖÔÚ£¬º¬ÓÐÒ©Îï·Ö×ÓµÄàçßòÓÃÓÚÖÎÁƸ÷ÖÖÖÐÊàÉñ¾­ÏµÍ³Ê§µ÷¼²²¡£¬Í¬Ê±´óÁ¿µÄàçßòÑÜÉúÎïĿǰҲÓÃÓÚÁÙ´²ÊÔÑé¡£

A lot of research has been carried out on thiazole and their analogues, which has proved their efficacy to overcome several CNS disorders in rodent as well as primate models. The aim of present review is to highlights diverse CNS activities displayed by thiazole and their derivatives. SAR of this nucleus has also been well discussed.
ÈËÃÇÒѾ­½øÐÐÁË´óÁ¿Ñо¿À´Ñо¿àçßò¼°ÆäÀàËÆÎÕâЩÑо¿ÒÑÖ¤Ã÷ÁËàçßòÔÚ¿Í·þÄö³Ý¶¯ÎïºÍÁ鳤ÀදÎï¸÷ÖÖÖÐÊàÉñ¾­ÏµÍ³Ê§µ÷¼²²¡µÄЧÂÊ¡£±¾×ÛÊöµÄÄ¿µÄÊÇ͹ÏÔàçßò¼°ÆäÑÜÉúÎïÔÚ¸÷ÖÖÖÐÊàÉñ¾­ÏµÍ³ÖеĻ¡£ºËÐĵÄSARÒ²ÒѾ­ºÜºÃµÄÌÖÂÛ¹ýÁË

This review covers the recent updates present in literature and will surely provide a greater insight for the designing and development of potent thiazole based CNS active agents in future.
±¾×ÛÊö°üº¬ÁË×î½üÎÄÏ׸üУ¬ºÁÎÞÒÉÎÊΪδÀ´»ùÓÚÖÐÊàÉñ¾­ÏµÍ³»îÐÔ¼ÁÑз¢ÓÐЧàçßòÌṩһÖÖ¸üеÄÊӽǡ£
2Â¥2016-05-02 18:50:32
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ jdy1947 µÄÖ÷Ìâ¸üÐÂ
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] ²ÄÁÏÓ뻯¹¤×¨Ë¶306·ÖÕÒºÏÊʵ÷¼Á +6 ²×º£ÇáÖÛe 2026-04-06 6/300 2026-04-06 10:02 by lqwchd
[¿¼ÑÐ] ²ÄÁÏר˶(0856) 339·ÖÇóµ÷¼Á +10 ¹þ¹þ¹þ¶ì¹þ¹þ¹þ 2026-04-05 10/500 2026-04-06 09:35 by jp9609
[¿¼ÑÐ] ¸´ÊÔµ÷¼Á +5 asdasdassda 2026-04-05 5/250 2026-04-06 09:32 by dongzh2009
[¿¼ÑÐ] Ò»Ö¾Ô¸211£¬»¯Ñ§Ñ§Ë¶£¬310·Ö£¬±¾¿ÆÖصãË«·Ç£¬Çóµ÷¼Á +13 ŬÁ¦·Ü¶·112 2026-04-04 13/650 2026-04-06 07:13 by jj987
[¿¼ÑÐ] ²ÄÁϹ¤³Ì302·ÖÇóµ÷¼Á +9 zyxÉϰ¶£¡ 2026-04-04 9/450 2026-04-05 22:08 by ×íÎÌwl
[¿¼ÑÐ] Ò»Ö¾Ô¸ ÄϾ©º½¿Õº½Ìì´óѧ £¬080500²ÄÁÏ¿ÆÑ§Ó빤³Ìѧ˶ +10 @taotao 2026-03-30 10/500 2026-04-05 17:57 by jj987
[¿¼ÑÐ] ¹¤¿ÆÇóµ÷¼Á +15 11ggg 2026-04-03 15/750 2026-04-05 16:24 by zzx2138
[¿¼ÑÐ] 298·Ö 070300Çóµ÷¼Á +15 zwen03 2026-04-02 15/750 2026-04-05 12:52 by Hdyxbekcb
[¿¼ÑÐ] ²ÄÁϹ¤³Ì085601Êý¶þÓ¢Ò»335Çóµ÷¼Á +6 Ë«ÂíβƦÀϰå2 2026-03-31 6/300 2026-04-04 22:29 by hemengdong
[¿¼ÑÐ] Ò»Ö¾Ô¸ÄÏÅ©090401£¬268£¬Çóµ÷¼Á +5 һľÄñÈ» 2026-04-04 5/250 2026-04-04 17:07 by babysonlkd
[¿¼ÑÐ] 348·Ö»·¾³¹¤³Ì¡¤µ÷¼Á +10 ÎâÑå׿24k 2026-04-03 11/550 2026-04-04 14:19 by Î޼ʵIJÝÔ­
[¿¼ÑÐ] 081200-11408-276ѧ˶Çóµ÷¼Á +5 ´Þwj 2026-04-03 5/250 2026-04-03 15:06 by arrow8852
[¿¼ÑÐ] ¹¤¿Æ 267Çóµ÷¼Á +5 wanwan00 2026-04-02 7/350 2026-04-03 14:14 by zhangdingwa
[¿¼ÑÐ] ר˶085601Çóµ÷¼Á +7 suyifei 2026-04-03 8/400 2026-04-03 14:00 by ÐÀϲ777
[¿¼ÑÐ] ²ÄÁϵ÷¼Á +4 Ò»ÑùYWY 2026-04-03 4/200 2026-04-03 09:48 by À¶ÔÆË¼Óê
[¿¼ÑÐ] Ò»Ö¾Ô¸ÏÃÃÅ´óѧ²ÄÁϹ¤³Ìר˶354ÕÒµ÷¼Á£¡£¡£¡ +8 ±´ß±µ±µ 2026-03-30 8/400 2026-04-03 09:41 by hypershenger
[¿¼ÑÐ] Ò»Ö¾Ô¸±±¾©¿Æ¼¼²ÄÁÏ¿ÆÑ§Ó빤³Ì288·Ö£¬Çóµ÷¼Á +14 Êdz½°¡ 2026-04-02 14/700 2026-04-02 21:10 by dongzh2009
[¿¼ÑÐ] 285Çóµ÷¼Á +14 AZMK 2026-04-02 14/700 2026-04-02 15:54 by ÉϾÅÌìÀ¿Ô£¨ºÃÔ
[¿¼ÑÐ] ÍÁľ304Çóµ÷¼Á +6 ÍÃͻͻͻ£¬ 2026-03-31 7/350 2026-04-02 09:06 by coolminer
[¿¼ÑÐ] 350Çóµ÷¼Á +7 °¢¼Ñ¡« 2026-03-31 7/350 2026-04-01 16:12 by yanflower7133
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û