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Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to display a variety of biological activities. Thiazole and its derivatives have attracted continuing interest to design various novel CNS active agents. In the past few decades, thiazoles have been widely used to develop a variety of therapeutic agents against numerous CNS targets. Thiazole containing drug molecules are currently being used in treatment of various CNS disorders and a number of thiazole derivatives are also presently in clinical trials. A lot of research has been carried out on thiazole and their analogues, which has proved their efficacy to overcome several CNS disorders in rodent as well as primate models. The aim of present review is to highlights diverse CNS activities displayed by thiazole and their derivatives. SAR of this nucleus has also been well discussed. This review covers the recent updates present in literature and will surely provide a greater insight for the designing and development of potent thiazole based CNS active agents in future. |
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jdy1947: 金币+50, 翻译EPI+1, ★★★★★最佳答案 2016-05-03 08:12:31
jdy1947: 金币+50, 翻译EPI+1, ★★★★★最佳答案 2016-05-03 08:12:31
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Thiazole is a valuable scaffold in the field of medicinal chemistry and has accounted to display a variety of biological activities. Thiazole and its derivatives have attracted continuing interest to design various novel CNS active agents. 作为医疗化学领域的一种重要的支架，噻唑能作用于各种生物活动中。人们一直在尝试基于噻唑和其衍生物设计各种新型活性剂。 In the past few decades, thiazoles have been widely used to develop a variety of therapeutic agents against numerous CNS targets. Thiazole containing drug molecules are currently being used in treatment of various CNS disorders and a number of thiazole derivatives are also presently in clinical trials. 在过去的几十年里，噻唑被广泛运用于开发各种的治疗剂，以治疗治疗中枢神经系统疾病。现在，含有药物分子的噻唑用于治疗各种中枢神经系统失调疾病，同时大量的噻唑衍生物目前也用于临床试验。 A lot of research has been carried out on thiazole and their analogues, which has proved their efficacy to overcome several CNS disorders in rodent as well as primate models. The aim of present review is to highlights diverse CNS activities displayed by thiazole and their derivatives. SAR of this nucleus has also been well discussed. 人们已经进行了大量研究来研究噻唑及其类似物，这些研究已证明了噻唑在客服啮齿动物和灵长类动物各种中枢神经系统失调疾病的效率。本综述的目的是凸显噻唑及其衍生物在各种中枢神经系统中的活动。核心的SAR也已经很好的讨论过了 This review covers the recent updates present in literature and will surely provide a greater insight for the designing and development of potent thiazole based CNS active agents in future. 本综述包含了最近文献更新，毫无疑问为未来基于中枢神经系统活性剂研发有效噻唑提供一种更新的视角。 |
2楼2016-05-02 18:50:32