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[求助]
SCI检索号查询-第一作者Qing Huang
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| 文章：Preparation and Cyclodextrin Solubilization of the Antibacterial Agent-Benzoyl Metronidazole |
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baiyuefei
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https://apps.webofknowledge.com/ ... age=1&doc=2 Preparation and Cyclodextrin Solubilization of the Antibacterial Agent Benzoyl Metronidazole 作者:Huang, Q (Huang, Qing)[ 1 ] ; Li, BP (Li, Benpeng)[ 1 ] ; Yang, S (Yang, Shuo)[ 1 ] ; Ma, PP (Ma, Peipei)[ 1 ] ; Wang, ZZ (Wang, Zhizhong)[ 1 ] SCIENTIFIC WORLD JOURNAL 文献号: 306476 DOI: 10.1155/2013/306476 出版年: 2013 查看期刊信息 SCIENTIFIC WORLD JOURNAL 出版商 HINDAWI PUBLISHING CORPORATION, 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA ISSN: 1537-744X 研究领域 Science & Technology - Other Topics 摘要 A one-pot method for the preparation of benzoyl metronidazole was achieved by using N,N'-carbonyldiimidazole as a coupling reagent. Moreover, it was found that the byproduct imidazole as the catalyst promoted the reaction. In addition, the beta-cyclodextrin solubilization of benzoyl metronidazole was investigated by phase-solubility method. The phase-solubility studies indicated that the solubility of benzoyl metronidazole (S = 0.1435 g/L) was substantially increased 9.7-fold (S' = 1.3881 g/L) by formation of 1:1 benzoyl metronidazole/beta-cyclodextrin complexes in water, and the association constant K-a value was determined to be 251 (+/- 23) dm(3)/mol. Therefore, beta-cyclodextrin can work as a pharmaceutical solubilizer for benzoyl metronidazole and may improve its oral bioavailability. 关键词 KeyWords Plus  ERIVATIVES 作者信息 通讯作者地址: Wang, ZZ (通讯作者) Ningxia Med Univ, Sch Pharm, Yinchuan 750004, Ningxia, Peoples R China. 增强组织信息的名称 Ningxia Medical University 地址: [ 1 ] Ningxia Med Univ, Sch Pharm, Yinchuan 750004, Ningxia, Peoples R China 增强组织信息的名称 Ningxia Medical University 电子邮件地址:zhizhongwang1976@163.com 基金资助致谢 基金资助机构 授权号 Undergraduate Innovation Project and Scientific Research Foundation of the Higher Education Institution of Ningxia NGY2012071 查看基金资助信息关闭基金资助信息 Undergraduate Innovation Project and Scientific Research Foundation of the Higher Education Institution of Ningxia (no. NGY2012071) are gratefully acknowledged. 出版商 HINDAWI PUBLISHING CORPORATION, 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA 类别 / 分类 研究方向:Science & Technology - Other Topics Web of Science 类别:Multidisciplinary Sciences 文献信息 文献类型:Article 语种:English 入藏号: WOS:000322699300001 ISSN: 1537-744X 其他信息 IDS 号: 195JW Web of Science 核心合集中的 "引用的参考文献": 9 Web of Science 核心合集中的 "被引频次": 2 JCR® 类别 JCR 分区 MULTIDISCIPLINARY SCIENCES Q2 数据来自第 2013 版 Journal Citation Reports® |
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