| 查看: 1229 | 回复: 20 | ||||
| 【奖励】 本帖被评价18次，作者york6999增加金币 14.2 个 | ||||
[资源]
Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies
|
||||
|
Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies José das Neves, Bruno Sarmento Springer- Published: 2014-02-17 ISBN: 1461495237 This book provides a concise and up-to-date overview of the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals as well as the technological strategies that have been followed so far regarding the optimization of mucosal potentialities. The book also addresses the challenges that arise with the advent of new biopharmaceutical drugs and alternative means of administration. After a brief introduction, the first section addresses general aspects of the biology of mucosal tissues and their unique aspects towards beneficial or deleterious interactions with biopharmaceuticals and delivery systems. The second part is dedicated to the different delivery strategies that have recently been investigated for different mucosal sites. The third section describes the development and clinical applications, either factual or potential, of particular pharmaceutical delivery systems and products enclosing biopharmaceuticals for mucosal delivery. Special focus is set on the most successful case studies of recent years by field experts or those engaged in developing such solutions in a concise and practical way. The last section briefly centers on pertinent aspects about the regulatory, toxicological and market issues of mucosal delivery of biopharmaceuticals. 2009. Contents Part I Biology of Mucosal Sites 1 Concepts in Mucosal Immunity and Mucosal Vaccines . . . . . . . . . . . . . 3 Simona Gallorini, Derek T. O’Hagan and Barbara C. Baudner 2 Mucoadhesion and Characterization of Mucoadhesive Properties . . . . 35 TaoYu, Gavin P. Andrews and David S. Jones 3 Mucus as a Barrier for Biopharmaceuticals and Drug Delivery Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Hongbo Zhang, Mohammed-Ali Shahbazi, Patrick V. Almeida and Hélder A. Santos 4 Epithelial Permeation and Absorption Mechanisms of Biopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 Hanne Mørck Nielsen Part II Delivery Strategies for Specific Mucosal Sites 5 Oral Delivery of Biopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 Catarina Oliveira Silva, Bruno Sarmento and Catarina Pinto Reis 6 Buccal Delivery of Biopharmaceuticals: Vaccines and Allergens . . . . . 149 Sevda ¸ Senel, Merve Cansız and Michael J. Rathbone 7 Pulmonary Delivery of Biopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . 169 Fernanda Andrade, Catarina Moura and Bruno Sarmento 8 Nasal Delivery of Biopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197 EijiYuba and Kenji Kono 9 Ocular Delivery of Biopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . . . . 221 Holly Lorentz and Heather Sheardown 10 Vaginal Delivery of Biopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . . . 261 José das Neves Part III Case Studies of Mucosal Delivery of Biopharmaceuticals 11 Nanoparticles-in-Microsphere Oral Delivery Systems (NiMOS) for Nucleic Acid Therapy in the Gastrointestinal Tract . . . . . . . . . . . . . 283 Shardool Jain and Mansoor Amiji 12 Bacteria-Based Vectors for Oral Gene Therapy . . . . . . . . . . . . . . . . . . . . 313 Yong Bai, Rachael Burchfield, Sangwei Lu and Fenyong Liu 13 Self-Assembled Polysaccharide Nanogels for Nasal Delivery of Biopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325 Tomonori Nochi,YoshikazuYuki, Kazunari Akiyoshi and Hiroshi Kiyono 14 PheroidTM Vesicles and Microsponges for Nasal Delivery of Biopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 333 Lissinda H. du Plessis and Awie F. Kotzé 15 Delivery Strategies for Developing siRNA-Based Vaginal Microbicides . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 345 Joseph A. Katakowski and Deborah Palliser 16 Delivery Strategies for Developing Vaginal DNA Vaccine Combining Cell-Penetrating Peptide and Jet Injection . . . . . . . . . . . . . . . . . . . . . . . . 367 Takanori Kanazawa and Hiroaki Okada 17 Vaccine Delivery Systems for Veterinary Immunization . . . . . . . . . . . . . 379 Juan M. Irache, Ana I. Camacho and Carlos Gamazo 18 Eligen® Technology for Oral Delivery of Proteins and Peptides . . . . . . 407 Sunita Prem Victor,Willi Paul and Chandra P. Sharma 19 The RapidMistTM System for Buccal Delivery of Insulin . . . . . . . . . . . . 423 Meena Bansal, Sanjay Bansal and Rachna Kumria 20 The Pharmaceutical Development of rhDNase (Dornase Alpha) for the Treatment of Cystic Fibrosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 437 Steven J. Shire and Thomas M. Scherer 21 Development of the Exubera® Insulin Pulmonary Delivery System . . . 461 Cynthia L. Stevenson and David B. Bennett 22 Technosphere®: An Inhalation System for Pulmonary Delivery of Biopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 483 António J. Almeida and Ana Grenha 23 ChiSys® as a Chitosan-Based Delivery Platform for Nasal Vaccination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 499 PeterWatts, Alan Smith and Michael Hinchcliffe 24 Development of a Cationic Nanoemulsion Platform (Novasorb®  for Ocular Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 517Frédéric Lallemand, Philippe Daull and Jean-Sébastien Garrigue Part IV Regulatory, Toxicological and Market Issues 25 Regulatory Aspects and Approval of Biopharmaceuticals for Mucosal Delivery: Quality, Toxicology, and Clinical Aspects . . . . . 539 Karen Brigitta Goetz,Yuansheng Sun, Katrin Féchir, Evelyne Kretzschmar and Isabel Buettel Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 591  002ced1a.jpg |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : MDBiopharmaceuticals.part1.rar
- 附件 2 : MDBiopharmaceuticals.part2.rar
2016-04-23 19:14:56, 3.91 M
2016-04-23 19:15:40, 3.09 M
» 收录本帖的淘帖专辑推荐
 Allen的英文原版+百科 | 药物制剂研发 |
» 猜你喜欢
请教限项目规定
已经有5人回复
-
拟解决的关键科学问题还要不要写
已经有8人回复
-
最失望的一年
已经有16人回复
-
存款400万可以在学校里躺平吗
已经有33人回复
-
求助一下有机合成大神
已经有3人回复
-
求推荐英文EI期刊
已经有5人回复
-
26申博
已经有3人回复
-
基金委咋了？2026年的指南还没有出来？
已经有10人回复
-
基金申报
已经有6人回复
-
疑惑？
已经有5人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 求助文献翻译
已经有0人回复
- springer出版的Host-Fungus Interactions Methods and Protocols（最新版）
已经有38人回复
简单回复
ha16682楼
2016-04-24 01:46
回复
五星好评 顶一下，感谢分享！
work0373楼
2016-04-24 20:17
回复
五星好评 顶一下，感谢分享！
xz_yu4楼
2016-04-27 08:21
回复
五星好评 顶一下，感谢分享！
qiute6215楼
2016-04-27 20:15
回复
五星好评 顶一下，感谢分享！
lhw79626楼
2016-04-27 20:47
回复
五星好评 顶一下，感谢分享！
2016-04-28 00:04
回复
五星好评 顶一下，感谢分享！
butte8楼
2016-04-28 09:25
回复
五星好评 顶一下，感谢分享！
chemasym9楼
2016-04-28 10:50
回复
五星好评 顶一下，感谢分享！
msd2phd10楼
2016-04-28 18:41
回复
五星好评 顶一下，感谢分享！
独叶一支枪11楼
2016-04-29 19:46
回复
五星好评 顶一下，感谢分享！
liqi_sywj12楼
2016-04-30 05:27
回复
五星好评 顶一下，感谢分享！
yzj197213楼
2016-04-30 10:44
回复
五星好评 顶一下，感谢分享！
chjshun14楼
2016-10-23 06:54
回复
五星好评 顶一下，感谢分享！
nihaoweiming15楼
2016-11-22 16:14
回复
五星好评 顶一下，感谢分享！
daoke200516楼
2017-03-19 15:53
回复
三星好评 顶一下，感谢分享！
abc7517楼
2017-04-21 13:57
回复
五星好评 顶一下，感谢分享！
cpu084511718楼
2018-06-08 13:49
回复
五星好评 顶一下，感谢分享！
cpu084511719楼
2019-11-22 22:14
回复
顶一下，感谢分享！
独孤久健20楼
2019-11-29 08:52
回复
五星好评 顶一下，感谢分享！
cpu084511721楼
2022-12-01 15:38
回复
顶一下，感谢分享！