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标题：A facile synthesis and application of ethyl 6-(bromomethyl)-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate 作者：Yang Li 期刊：Research on Chemical Intermeidates 年份：2015 期卷页码：41卷，第7期，4977–4985页 DOI号：10.1007/s11164-014-1581-1 |
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liyang1580: 金币+20, ★★★★★最佳答案 2016-04-19 17:23:47
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lazy锦溪: LS-EPI+1, 感谢应助！ 2016-04-19 18:02:32
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A facile synthesis and application of ethyl 6-(bromomethyl)-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate 作者:Li, Y (Li, Yang) RESEARCH ON CHEMICAL INTERMEDIATES 卷: 41 期: 7 页: 4977-4985 DOI: 10.1007/s11164-014-1581-1 出版年: JUL 2015 查看期刊信息 RESEARCH ON CHEMICAL INTERMEDIATES 出版商 SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS ISSN: 0922-6168 eISSN: 1568-5675 研究领域 Chemistry 摘要 Visible-light-induced radical bromination of ethyl 6-methyl-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate (1) was effectively conducted with N-bromosuccinimide using a 150-W tungsten bulb as an initiator, leading to the desired monobromo product ethyl 6-(bromomethyl)-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate (2) in good yield of 76 %. Using the present procedure, a 46 % improvement in yield of 2 was achieved when compared with the previous method used by us. In addition, the trace amount of byproduct was isolated and identified as ethyl 9-bromo-6-methyl-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate (3) based on H-1 nuclear magnetic resonance (NMR) spectral analysis. As an extended application of 2, a new synthesis of symmetrical 2-quinolylmethoxyphenyl-containing diethers 11a-c was achieved via Williamson reaction with some dihydroxy arenes (10a-c). 关键词 作者关键词:Radical bromination; Quinoline; N-Bromosuccinimide; Tungsten bulb; Williamson reaction; Diether KeyWords Plus:LEUKOTRIENE-D4 RECEPTOR ANTAGONISTS; (2-QUINOLINYLMETHOXY)PHENYL-CONTAINING COMPOUNDS; N-BROMOSUCCINIMIDE; AFFINITY; SERIES; DERIVATIVES; BROMINATION; INHIBITORS; WATER; RING 作者信息 通讯作者地址: Li, Y (通讯作者) Bohai Univ, Inst Superfine Chem, Jinzhou 121000, Peoples R China. 地址: [ 1 ] Bohai Univ, Inst Superfine Chem, Jinzhou 121000, Peoples R China 电子邮件地址:bhuzh@163.com 基金资助致谢 基金资助机构 授权号 Scientific Research Foundation of the Education Department of Liaoning Province L2013428 查看基金资助信息关闭基金资助信息 The authors would like to thank the Scientific Research Foundation of the Education Department of Liaoning Province (grant no. L2013428) for financial support. 出版商 SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS 类别 / 分类 研究方向:Chemistry Web of Science 类别:Chemistry, Multidisciplinary 文献信息 文献类型:Article 语种:English 入藏号: WOS:000356608700071 ISSN: 0922-6168 eISSN: 1568-5675 期刊信息 目录： Current Contents Connect® 其他信息 IDS 号: CL0DG Web of Science 核心合集中的 "引用的参考文献": 20 Web of Science 核心合集中的 "被引频次": 0 影响因子 1.221 1.141 2014 5 年 JCR® 类别 类别中的排序 JCR 分区 CHEMISTRY, MULTIDISCIPLINARY 92/157 Q3 数据来自第 2014 版 Journal Citation Reports® |
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