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[求助] BCS分类已有1人参与

苯甲酸阿格列汀的BCS分类是几类啊？

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1楼 2016-04-11 11:33:27

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狼行拂晓

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-feisha-: 金币+10, ★★★★★最佳答案 2016-04-13 16:32:15

欧盟审评报告中写的是BCS I类。
具体这一段落原话如下：
Metformin hydrochloride (BCS class III) is freely soluble in aqueous media. Alogliptin benzoate (BCS class I) is sparingly soluble in water from pH 3-11 and particle size was demonstrated to have no effect on dissolution profile. Nonetheless, a specification for alogliptin benzoate is included to ensure the particle size distribution falls within a justified range. Excipients were chosen to maximise hardness, reduce friability, and maximise disintegration and dissolution time but also based on their compatibility with the active substances, which were also shown to be mutually stable.

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2楼2016-04-11 15:43:55

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2楼: Originally posted by 狼行拂晓 at 2016-04-11 15:43:55
欧盟审评报告中写的是BCS I类。
具体这一段落原话如下：
Metformin hydrochloride (BCS class III) is freely soluble in aqueous media. Alogliptin benzoate (BCS class I) is sparingly soluble in water from ...

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3楼2016-04-13 16:51:56

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