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µÚÒ»¾ä»°£ºIt is likely that some elements of this wave structure are influenced by the bolus nature of the injection model in contrast to the more continual release of CTCs expected in spontaneous metastasis
µÚ¶þ¾ä»°£ºIn contrast, tumour-loaded patrolling monocytes and neutrophils remained intravascular throughout. The DC populations that gathered tumour material remained largely extravascular throughout, with the exception of a very small but consistent population of ZsGreen+ DCs, at 4 h, that stained for i.v. CD45, which may reflect intravascular sampling by these DC populations
µÚÈý¾ä»°£ºWe next sought to determine how cytoplast-ingesting cells behaved with respect to extravasation.
µÚËľ仰£ºAlthough our analysis of tumour-interacting myeloid cells strongly supports waves of recruited neutrophils, monocytes and macrophages as populations of interest in the early metastatic niche, it also reveals the presence of rare lung-resident cDC subsets within the early interacting pool that mediate potent anti-metastatic effects

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In contrast, tumour-loaded patrolling monocytes and neutrophils remained intravascular throughout. The DC populations that gathered tumour material remained largely extravascular throughout, with the exception of a very small but consistent population of ZsGreen+ DCs, at 4 h, that stained for i.v. CD45, which may reflect intravascular sampling by these DC populationsÓë´ËÏà·´£¬Ö×ÁöÖÐÆðѲÂß¹¦Äܵĵ¥ºËϸ°ûºÍÊÉÖÐÐÔÁ£Ï¸°ûÖ÷Òª·Ö²¼ÔÚѪ¹ÜÄÚ¡£ÒÑÊÕ¼¯ÁËÖ×ÁöÎïÖʵÄÊ÷ͻ״ϸ°ûȺÌåÖ÷Òª±é²¼ÔÚѪ¹ÜÍ⣬³ýÁ˼«ÉÙµ«ÊÇʼÖÕ´æÔڵľßZsGreenÑôÐÔÌØÕ÷µÄÊ÷ͻ״ϸ°ûȺÌå, ¸Ãϸ°ûȺÌåÔÚ4Сʱʱ¼äµãÒÔCD45ÑôÐÔ£¬ÑªÒºÖÐÐÎʽ´æÔÚ¡£
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