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第一句话：It is likely that some elements of this wave structure are influenced by the bolus nature of the injection model in contrast to the more continual release of CTCs expected in spontaneous metastasis 第二句话：In contrast, tumour-loaded patrolling monocytes and neutrophils remained intravascular throughout. The DC populations that gathered tumour material remained largely extravascular throughout, with the exception of a very small but consistent population of ZsGreen+ DCs, at 4 h, that stained for i.v. CD45, which may reflect intravascular sampling by these DC populations 第三句话：We next sought to determine how cytoplast-ingesting cells behaved with respect to extravasation. 第四句话：Although our analysis of tumour-interacting myeloid cells strongly supports waves of recruited neutrophils, monocytes and macrophages as populations of interest in the early metastatic niche, it also reveals the presence of rare lung-resident cDC subsets within the early interacting pool that mediate potent anti-metastatic effects |
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genhunter
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- 专业: 肿瘤化学药物治疗
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加菲菲: 金币+5, 翻译EPI+1, ★★★很有帮助 2016-04-05 11:15:16
加菲菲(RXMCDM代发): 金币+5 2016-04-09 19:41:19
加菲菲: 金币+5, 翻译EPI+1, ★★★很有帮助 2016-04-05 11:15:16
加菲菲(RXMCDM代发): 金币+5 2016-04-09 19:41:19
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It is likely that some elements of this wave structure are influenced by the bolus nature of the injection model in contrast to the more continual release of CTCs expected in spontaneous metastasis 有可能这种波浪型结构(或曲线，要看前后文)中的某些因素是受到一次性注射模式的特征的所影响，与在肿瘤自发转移时CTC的连续释放不同。 In contrast, tumour-loaded patrolling monocytes and neutrophils remained intravascular throughout. The DC populations that gathered tumour material remained largely extravascular throughout, with the exception of a very small but consistent population of ZsGreen+ DCs, at 4 h, that stained for i.v. CD45, which may reflect intravascular sampling by these DC populations与此相反，肿瘤中起巡逻功能的单核细胞和噬中性粒细胞主要分布在血管内。已收集了肿瘤物质的树突状细胞群体主要遍布在血管外，除了极少但是始终存在的具ZsGreen阳性特征的树突状细胞群体, 该细胞群体在4小时时间点以CD45阳性，血液中形式存在。 We next sought to determine how cytoplast-ingesting cells behaved with respect to extravasation. 下一步我们测定了吞噬了细胞体后的细胞如何迁移出毛细血管。 Although our analysis of tumour-interacting myeloid cells strongly supports waves of recruited neutrophils, monocytes and macrophages as populations of interest in the early metastatic niche, it also reveals the presence of rare lung-resident cDC subsets within the early interacting pool that mediate potent anti-metastatic effects尽管我们对与肿瘤发生相互作用的源于骨髓的细胞支持在肿瘤转移早期时以波浪型方式吸引关注的细胞群体，如噬中性粒细胞, 单核细胞和巨噬细胞，这种模式，我们也揭示了在参与早期作用的细胞群体中有相对少见的寄宿在肺部的C型树突状细胞子群体，起到很强的抗肿瘤转移效应。 |
2楼2016-04-01 17:03:40
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