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The outer edges of the Lzr gene cluster were defined based on comparisons to the BE-54017 and cladoniamide gene clusters and a BLAST analysis of genes surrounding the core indolotryptoline biosynthesis genes (Fig. 3A). The biosynthesis of indolotryptolines is well-characterized, making it possible to predict the function of most genes in the Lzr gene cluster (32). The four key stages of indolotryptoline biosynthesis involve dimerization of oxo-tryptophan to form a chromopyrrolic acid, oxidative aryl–aryl coupling to form an indolocarbazole, “flipping” of one of the indole rings to form an indolotryptoline, and tailoring to generate the final product. The Lzr gene cluster is predicted to contain seven transcriptional units controlled by three bidirectional (P1, P2, and P3) and one unidirectional (P4) promoter regions (Fig. 3 B, i). This cluster is conveniently organized such that successive activation of the three bidirectional promoter regions (P1, P2, and P3) is predicted to drive the expression of genes required to achieve the first, second, and third stages in indolotryptoline biosynthesis, respectively (Fig. 3C). |
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The outer edges of the Lzr gene cluster were defined based on comparisons to the BE-54017 and cladoniamide gene clusters and a BLAST analysis of genes surrounding the core indolotryptoline biosynthesis genes (Fig. 3A). The biosynthesis of indolotryptolines is well-characterized, making it possible to predict the function of most genes in the Lzr gene cluster (32). The four key stages of indolotryptoline biosynthesis involve dimerization of oxo-tryptophan to form a chromopyrrolic acid, oxidative aryl–aryl coupling to form an indolocarbazole, “flipping” of one of the indole rings to form an indolotryptoline, and tailoring to generate the final product. The Lzr gene cluster is predicted to contain seven transcriptional units controlled by three bidirectional (P1, P2, and P3) and one unidirectional (P4) promoter regions (Fig. 3 B, i). This cluster is conveniently organized such that successive activation of the three bidirectional promoter regions (P1, P2, and P3) is predicted to drive the expression of genes required to achieve the first, second, and third stages in indolotryptoline biosynthesis, respectively (Fig. 3C). 通过与BE-54017 和 cladoniamide 基因簇比较以及对 indolotryptoline生物合成核心基因的外围基因进行比对分析(Fig. 3A)来确定 Lzr 基因簇的外部边界。Indolotryptolines的生物合成特点突出，根据这些特点可预测lzr基因簇中很多基因的功能。Indolotryptolines生物合成的四个主要的步骤包括氧络色氨酸的二聚化形成chromopyrrolic acid，氧化芳基连接成indolocarbazole，一个吲哚环翻转形成indolotryptoline，修饰形成最终产物。预测lzr基因簇含有七个转录单位，它们由三个双向(P1, P2, 和 P3)，一个单向(P4)的启动子区域控制(Fig. 3 B, i)。该基因簇的排列使人很易想到三个双向启动子区域(P1, P2, 和 P3)的相继启动是分别促使indolotryptoline生物合成的第一步，第二步，第三步反应所需的基因的表达。 |
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