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| 结果显示：模型组小鼠肺组织中PI3K、AKT1/2及NF-κBp65蛋白的表达水平在不同时间均高于正常组（p＜0.05），PI3K、AKT1/2于感染第5天时表达最高，NF-κBp65表达呈持续增高状态。与模型组比较，桑白皮黄酮组小鼠肺组织中PI3K、AKT1/2蛋白的表达水平在各时间点显著降低（p＜0.05），NF-κBp65于感染第5、7天时表达水平显著降低（p＜0.05）；桑白皮多糖组小鼠肺组织中PI3K蛋白的表达水平于感染第3 、5天时显著降低（p＜0.05），AKT1/2蛋白的表达水平于感染第3、7天时显著降低（p＜0.05），NF-κBp65蛋白的表达水平各时间点均显著降低（p＜0.05）。结 论：1、采用RSV long株经鼻腔连续滴鼻的方法可以成功造出RSV感染幼龄BALB/c小鼠RSV肺炎模型。2、RSV感染小鼠后，可引起小鼠血清IFN-γ、IL-4与肺组织PI3K、AKT1/2及NF-κBp65表达的改变。3、桑白皮不同有效成分可以调控RSV肺炎小鼠PI3K/AKT信号通路与血清IFN-γ、IL-4的表达，其可能是桑白皮防治RSV肺炎、减轻其炎症反应的作用机制之一。关键词：呼吸道合胞病毒（RSV）；BALB/c小鼠；桑白皮；IFN-γ；IL-4；PI3K/AKT/ NF-κB信号通路；肺炎 |
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4楼2016-03-17 20:56:22
genhunter
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| The results showed that the levels of PI3K and AKT1 / 2 and NF-κB p65 protein expression on different time were higher in the lung tissue of mice from the model group than those of the normal group (P < 0.05), the expression levels of PI3K and AKT1 / 2 peaked by day 5, while the NF-κB p65 expression was persistently elevated. Compared with the lung tissues from the model group, those from Cortex mori flavonoids-treated (and infected) mice had significantly reduced PI3K and AKT1 / 2 protein expression levels in all time points (P < 0.05), and the NF-κB p65 levels were significantly reduced (P < 0.05) in lungs from the infected mice on days 3, and 5; In Cortex mori polysaccharides-treated mice group, the lung PI3k expression levels were also significantly decreased (P < 0.05) on days 3 and 5 post infection, the expression levels of AKT1 / 2 were significantly reduced (P < 0.05) on days 3 and 7 post infection and , NF-κB p65 protein expression level were significantly lower (P < 0.05) in all time point. Conclusion: 1, successive intranasal infection with the RSV long strains can successfully generate RSV pneumonia model in young BALB / c mice. 2, RSV infection can trigger changes in the levels of serum IFN-γ and IL-4 mice, and PI3K, AKT1/2 and NF-kB p65 expression levels in lung tissue. 3, the white bark from mulberry root have different active ingredients that can regulate the PI3K, Akt signaling pathways and serum IFN gamma, IL-4 expressions in mice with RSV pneumonia, which may be the mechanism of action for Mulberry bark in prevention and treatment of RSV pneumonia, and alleviating the severity of inflammatory reaction. Keywords: respiratory syncytial virus (RSV); BALB / c mice; Mulberry bark; IFN-γ; IL-4; PI3K/AKT/ NFκB signaling pathways; pneumonia |
3楼2016-03-17 20:11:30
