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【答案】应助回帖
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vxiaoxue: 金币+65, 翻译EPI+1, ★★★很有帮助, 救急啦，棒棒哒 2016-03-17 20:41:20
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The results showed that the levels of PI3K and AKT1 / 2 and NF-κB p65 protein expression on different time were higher in the lung tissue of mice from the model group than those of the normal group (P < 0.05), the expression levels of PI3K and AKT1 / 2 peaked by day 5, while the NF-κB p65 expression was persistently elevated. Compared with the lung tissues from the model group, those from Cortex mori flavonoids-treated (and infected) mice had significantly reduced PI3K and AKT1 / 2 protein expression levels in all time points (P < 0.05), and the NF-κB p65 levels were significantly reduced (P < 0.05) in lungs from the infected mice on days 3, and 5; In Cortex mori polysaccharides-treated mice group, the lung PI3k expression levels were also significantly decreased (P < 0.05) on days 3 and 5 post infection, the expression levels of AKT1 / 2 were significantly reduced (P < 0.05) on days 3 and 7 post infection and , NF-κB p65 protein expression level were significantly lower (P < 0.05) in all time point. Conclusion: 1, successive intranasal infection with the RSV long strains can successfully generate RSV pneumonia model in young BALB / c mice. 2, RSV infection can trigger changes in the levels of serum IFN-γ and IL-4 mice, and PI3K, AKT1/2 and NF-kB p65 expression levels in lung tissue. 3, the white bark from mulberry root have different active ingredients that can regulate the PI3K, Akt signaling pathways and serum IFN gamma, IL-4 expressions in mice with RSV pneumonia, which may be the mechanism of action for Mulberry bark in prevention and treatment of RSV pneumonia, and alleviating the severity of inflammatory reaction. Keywords: respiratory syncytial virus (RSV); BALB / c mice; Mulberry bark; IFN-γ; IL-4; PI3K/AKT/ NFκB signaling pathways; pneumonia |
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