| 查看: 447 | 回复: 0 | ||
[求助]
求译Biosynthesis of Lycosantalonol a cis-Prenyl Derived Diterpenoid论文摘要
|
|
Terpenoid natural products are generally derived from isoprenyl diphosphate precursors with trans double-bond configuration, and no diterpenoid derived from the cisoid precursor (Z,Z,Z)-nerylneryl diphosphate (1) has yet been identified. Here further investigation of a terpenoid biosynthetic gene cluster from tomato is reported, which resulted in identification of a biosynthetic pathway from 1, in a pathway featuring a number of interesting transformations. Compound 1 is first cyclized to a tricyclene core ring structure analogous to that found in α-santalene, with the resulting diterpene termed here lycosantalene (2). Quantum chemical calculations indicate a role for the diphosphate anion coproduct in this cyclization reaction. Subsequently, the internal cis double bond of the neryl side chain in 2 is then further transformed to an α-hydroxy ketone moiety via an epoxide intermediate (3). Oxygen labeling studies indicate 3 undergoes oxidative conversion to lycosantalonol (4). Thus, in addition to elucidating the cisoid origins of 4, this work has further provided mechanistic insight into the interesting transformations required for its production. |
» 猜你喜欢
295求调剂
已经有15人回复
一志愿河北工业大学材料工程,初试344求专硕调剂
已经有6人回复
362求调剂一志愿中国石油大学
已经有5人回复
0703调剂,一志愿天津大学319分
已经有13人回复
085600材料与化工专硕329 求调剂
已经有4人回复
化工求调剂!
已经有4人回复
材料调剂
已经有5人回复
求调剂 一志愿西南交通大学085701环境工程 282分
已经有8人回复
265求调剂
已经有3人回复
302分求调剂 一志愿安徽大学085601
已经有9人回复















回复此楼