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求翻译摘要2篇，急，谢谢，简单翻译了，请修改
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Non-invasive exhaled volatile organic biomarker analysis to detect inflammatory bowel disease (IBD) 消化道 非侵入性的呼出挥发性有机生物标志物分析检测炎症性肠病（IBD） Introduction: Early inflammatory bowel disease (IBD) diagnosis remains a clinical challenge. Volatile organic compounds (VOCs) have shown distinct patterns in Crohn’s disease (CD) and ulcerative col-itis (UC). VOC production, reflecting gut fermentome metabolites, is perturbed in IBD. VOC sampling is non-invasive, with various compounds identified from faecal, breath and urine samples. This study aimed to determine if FAIMS (field asymmetric ion mobility spectroscopy) analysis of exhaled VOCs could distinguish IBD from controls. Methods: Seventy-six subjects were recruited, 54 established IBD (25 CD, 29 UC) and 22 healthy con-trols. End expiratory breath was captured using a Warwick device and analysed by FAIMS. Data were pre-processed using wavelet transformation, and classification performed in a 10-fold cross-validation. Feature selection was performed using Wilcoxon rank sum test, and sparse logistic regression gave class predictions, to calculate sensitivity and specificity. Results: FAIMS breath VOC analysis showed clear separation of IBD from controls, sensitivity: 0.74 (0.65–0.82), specificity: 0.75 (0.53–0.90), AUROC: 0.82 (0.74–0.89), p-value 6.2 × 10−7 . IBD subgroup anal-ysis distinguished UC from CD: sensitivity of 0.67 (0.54–0.79), specificity: 0.67 (0.54–0.79), AUROC: 0.70 (0.60–0.80), p-value 9.23 × 10−4 . Conclusion: This confirms the utility of exhaled VOC analysis to distinguish IBD from healthy controls, and UC from CD. It conforms to other studies using different technology, whilst affirming exhaled VOCs as biomarkers for diagnosing IBD.介绍：早期的炎症性肠病（IBD）的诊断仍然是临床的挑战。挥发性有机化合物（VOCs）在克罗恩病（CD）和溃疡性结肠炎的不同模式的关口，（UC）。挥发性有机化合物的生产，反映肠道fermentome代谢物，扰动在IBD。VOC采样是非侵入性的，与各种化合物从粪便、呼吸和尿液样本。本研究的目的是确定如果FAIMS（场非对称离子迁移谱）呼出VOCs分析可以区分IBD对照。 方法：选取七零六例，54建立IBD（25 CD、UC 29）和22例健康对照组。呼气末呼气使用华威装置对FAIMS捕获。数据进行预处理，使用小波变换，并在10倍交叉验证进行分类。特征选择是采用Wilcoxon秩和检验进行，稀疏Logistic回归了类的预测，计算敏感性和特异性。 结果：呼吸VOC分析表明FAIMS IBD控制，灵敏度明显分离：0.74（0.65–0.82），特异性0.75（0.53–0.90），下：0.82（0.74–0.89），P值6.2×10−7。IBD亚组分析区分UC与CD：敏感性0.67，特异性（0.54–0.79）：0.67（0.54–0.79），下：0.70（0.60–0.80），P值9.23×10−4。 结论：这证实呼出VOC分析区分IBD健康对照者的效用，和UC与CD。它符合其他研究使用不同的技术，同时肯定呼出VOCs作为诊断IBD的生物标志物。 |
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