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求翻译摘要2篇，急，谢谢，简单翻译了，请修改
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Abstract Background & Aims—Selected-ion flow-tube mass spectrometry (SIFT-MS) can precisely identify trace gases in the human breath, in the parts-per-billion range. We investigated whether concentrations of volatile compounds in breath samples correlate with the diagnosis of alcoholic hepatitis (AH) and the severity of liver disease in patients with AH. Methods—We recruited patients with liver disease from a single tertiary care center. The study population was divided those with AH with cirrhosis (n=40) and those with cirrhosis with acute decompensation from etiologies other than alcohol (n=40); individuals without liver disease served as controls (n=43). We used SIFT-MS to identify and measure 14 volatile compounds in breath samples from fasted subjects. We used various statistical analyses to compare clinical characteristics and breath levels of compounds among groups, and test the correlation between levels of compounds and severity of liver disease. Logistic regression analysis was performed to build a predictive model for AH. Results—We identified 6 compounds (2-propanol, acetaldehyde, acetone, ethanol, pentane and trimethylamine [TMA]) whose levels were increased in patients with liver disease compared with controls. Mean concentrations of TMA, acetone, and pentane were particularly high in breath samples from patients with AH, compared to those with acute decompensation or controls (for both, P<.001). Using receiver operating characteristic curve analysis, we developed a model for the diagnosis of AH based on breath levels of TMA, acetone, and pentane (TAP). TAP scores of 36 or higher identified the patients with AH (AUC=0.92), with 90% sensitivity and 80% specificity. The levels of exhaled TMA had a low level of correlation with the severity of AH based on model for end-stage liver disease score (r=0.38; 95% confidence interval, 0.07–0.69; P=. 018]. Conclusion—Based on levels of volatile compounds in breath samples, we can identify patients with AH vs patients with acute decompensation or individuals without liver disease. Levels of exhaled TMA moderately correlate with the severity of AH. These findings might be used in diagnosis of AH or in determining patient prognosis. 背景与目的:选择离子流动管质谱（SIFT-MS）可以准确识别在人类呼吸的微量气体，在十亿范围。我们调查是否在呼吸样品中的挥发性化合物的浓度与酒精性肝炎（啊）和患者的肝脏疾病的严重程度相关。 方法:从单一的三级医疗中心招募肝病患者。研究人群分为那些啊肝硬化患者（n = 40）和那些与酒精以外的其他病因急性失代偿期肝硬化患者（n = 40）；无肝脏疾病作为对照者（n = 43）。我们用SIFT-MS识别和测量在呼吸样本14挥发性化合物禁食。我们用不同的统计分析比较了各组间化合物的临床特征和呼吸水平，并检验了化合物的含量与肝脏疾病的严重程度之间的关系。建立一个预测模型，进行逻辑回归分析。 我们鉴定了6个化合物的结果（异丙醇、乙醛、丙酮、乙醇、和三甲胺[ TMA ]戊烷）的水平升高，肝脏疾病患者与对照组相比。平均TMA，丙酮和戊烷浓度，尤其高呼吸的患者样本啊，相比那些急性失代偿或控制（包括，P<0。001）。应用ROC曲线分析，我们开发了一个基于TMA，丙酮呼吸水平啊的诊断模型，和戊烷（TAP）。挖掘36或更高的分数确定啊（AUC = 0.92）的患者中，有90%的敏感性和80%的特异性。呼出的TMA含量水平较低的基础上与终末期肝病模型啊严重程度相关（r = 0.38；95%置信区间，0.07–0.69；P =。018 ]。 结论基于呼气样本中的挥发性化合物的水平，我们可以识别啊VS患者急性失代偿或个人无肝脏疾病的患者。呼出的TMA与严重程度中度相关水平啊。这些发现可能用于诊断或确定病人的预后。 |
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