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迎国庆送The Practice of Medicinal Chemistry (Third Edition) 本帖停止更新
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【本贴首发于chem8er】 http://chem8.org/bbs/thread-19425-1-1.html  这是在药物化学领域被成为圣经（Medicinal Chemists's Bible）的一本好书！刚出最新之第三版！ 恰值国庆，免费送出此书，以飨所有emucher！ 得到一本电子书或许不难，难的是要勤读细读，真正从书中有所得，不要让它只是静静地躺在你的硬盘中，或者是当与他人谈起时只平添一句“我有这书的电子版的”罢了！ 该版仍然涵盖了药物化学研究领域“从头到脚”的概念介绍、历史发展与研究实例，更新了最近5年的研究结果，增加了11章节的新内容，内容涵盖药物研究的传统方法和最新技术。与前几版本相比，本版的一个主要变化就是全书分成了8个section，有主编和另外7个section editors各自负责一个section；另一个主要的变化就是全书为彩色，这为该书增色不少，使我们在获取知识的过程中有了难得的享受！看一本彩色内容的书和看一本全是密密麻麻文字的书的心情和效果之大相径庭，想必大家都深有体会! 该书不仅是初识药物化学者的一本很好的入门书籍，也是药物化学研究者案头必备之书，对于整个生命科学领域的学者而言也是一本难得的好书，对于非专业领域人事而言书中的不少内容也是很有价值的！ 未设置金币限制，免费下载，作为国庆佳节的一份贺礼吧！ http://www.box.net/shared/hdxeo0g7so 密码 www.chem8.org 本下载地址长期有效，如果谁要传于国内下载地址，请在本帖下方跟帖，勿重开新帖或求助，深为重复发帖恼，它已大大影响了emuch的版面质量！ 请版主协助吧！ 本帖停止更新，请至另一帖http://muchong.com/bbs/viewthread.php?tid=985332查看进一步信息！ 以下为该书目录： The Practice of Medicinal Chemistry (Third Edition) By Camille Wermuth, Prestwick Chemical, Illkirch, France Publisher: Academic Press Number Of Pages: 982 Publication Date: 2008-07-23 ISBN-10 / ASIN: 0123741947 ISBN-13 / EAN: 9780123741943 Binding: Hardcover Description Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making faster, more accurate identifications of the active substances that could potentially treat the disorder they are researching. New chapters on Drug Absorption & Transport give pharmaceutical scientists information on how potential drugs can move through the drug discovery/development phases more quickly. This third edition still stands as the only source for practical aspects of medicinal chemistry by focusing on the daily problems met by the medicinal chemist in drug discovery. Audience Pharmaceutical researchers in drug discovery, chemists Table of Contents Biography, Pages xxv-xxvi Contributors, Pages xxix-xxxiii Preface to the First Edition, Pages xxxv-xxxvi Preface to the Second Edition, Pages xxxvii-xxxviii Preface to the Third Edition, Page xxxix Part I: General Aspects of Medicinal Chemistry Chapter 1 - A History of Drug DiscoveryFrom first steps of chemistry to achievements in molecular pharmacology, Pages 1-62, François Chast Chapter 2 - Medicinal ChemistryDefinitions and Objectives, Drug Activity Phases, Drug Classification Systems, Pages 63-72, Peter Imming Chapter 3 - Measurement and Expression of Drug Effects, Pages 73-84, Jean-Pierre Nowicki, Bernard Scatton Chapter 4 - Molecular Drug Targets, Pages 85-105, Jean-Pierre Gies, Yves Landry Chapter 5 - Drug Targets, Target identification, Validation and Screening, Pages 106-121, Kenton H. Zavitz, Paul L. Bartel, Adrian N. Hobden Part II: Lead Compound Discovery Strategies Chapter 6 - Strategies in the Search for New Lead Compounds or Original Working Hypotheses, Pages 123-143, Camille G. Wermuth Chapter 7 - High-Throughput Screening and Drug Discovery, Pages 144-158, John R. Proudfoot Chapter 8 - Natural Products as Pharmaceuticals and Sources for Lead Structures, Pages 159-186, David J. Newman, Gordon M. Cragg, David G. I. Kingston Chapter 9 - Biology Oriented Synthesis and Diversity Oriented Synthesis in Compound Collection Development, Pages 187-209, Kamal Kumar, Stefan Wetzel, Herbert Waldmann Chapter 10 - In Silico ScreeningHit Finding from Database Mining, Pages 210-227, Thierry Langer, Sharon D. Bryant Chapter 11 - Fragment-Based Drug Discovery, Pages 228-243, Bennett T. Farmer, Allen B. Reitz Chapter 12 - Lead-Likeness and Drug-Likeness, Pages 244-254, Alex Polinsky Chapter 13 - Web AlertUsing the Internet for Medicinal Chemistry, Pages 255-272, David Cavalla Part III: Primary Exploration of Structure–Activity Relationships Chapter 14 - Molecular Variations in Homologous SeriesVinylogues and Benzologues, Pages 273-289, Camille G. Wermuth Chapter 15 - Molecular Variations Based on Isosteric Replacements, Pages 290-342, Paola Ciapetti, Bruno Giethlen Chapter 16 - Ring Transformations, Pages 343-362, Christophe Morice, Camille G. Wermuth Chapter 17 - Conformational Restriction and/or Steric Hindrance in Medicinal Chemistry, Pages 363-379, André Mann Chapter 18 - Homo and Heterodimer Ligands: the Twin Drug Approach, Pages 380-414, Jean-Marie Contreras, Wolfgang Sippl Chapter 19 - Application Strategies for the Primary Structure–Activity Relationship Exploration, Pages 415-427, Camille G. Wermuth Part IV: Substituents and Functions: Qualitative and Quantitative Aspects of Structure–Activity Relationships Chapter 20 - Substituent Groups, Pages 429-463, Patrick Bazzini, Camille G. Wermuth Chapter 21 - The Role of Functional Groups in Drug–Receptor Interactions, Pages 464-480, Laurent Schaeffer Chapter 22 - Compound Properties and Drug Quality, Pages 481-490, Christopher A. Lipinski Chapter 23 - Quantitative Approaches to Structure–Activity Relationships, Pages 491-513, Han van de Waterbeemd, Sally Rose Part V: Spatial Organization, Receptor Mapping and Molecular Modeling Chapter 24 - OverviewThe Search for Biologically Useful Chemical Space, Pages 515-520, David J. Triggle Chapter 25 - Pharmacological Space, Pages 521-532, Andrew L. Hopkins Chapter 26 - Optical Isomerism in Drugs, Pages 533-548, Camille G. Wermuth Chapter 27 - Multi-target DrugsStrategies and Challenges for Medicinal Chemists, Pages 549-571, Richard Morphy, Zoran Rankovic Chapter 28 - Pharmacophore Identification and Pseudo-Receptor Modeling, Pages 572-586, Wolfgang Sippl Chapter 29 - 3D Quantitative Structure–Property Relationships, Pages 587-604, Thierry Langer, Sharon D. Bryant Chapter 30 - Protein Crystallography and Drug Discovery, Pages 605-634, Jean-Michel Rondeau, Herman Schreuder Part VI: Chemical Modifications Infl uencing the Pharmacokinetic Properties Chapter 31 - Physiological Aspects Determining the Pharmacokinetic Properties of Drugs, Pages 635-654, Koen Boussery, Frans M. Belpaire, Johan Van de Voorde Chapter 32 - Biotransformation Reactions and Their Enzymes, Pages 655-673, Bernard Testa Chapter 33 - Biotransformations Leading to Toxic MetabolitesChemical Aspect, Pages 674-696, Anne-Christine Macherey, Patrick M. Dansette Chapter 34 - Drug Transport Mechanisms and their Impact on the Disposition and Effects of Drugs, Pages 697-710, Jean-Michel Scherrmann Chapter 35 - Strategies for Enhancing Oral Bioavailability and Brain Penetration, Pages 711-720, Brian C. Shook, Paul F. Jackson Chapter 36 - Designing Prodrugs and Bioprecursors, Pages 721-746, Camille G. Wermuth Part VII: Pharmaceutical and Chemical Means to Solubility and Formulation Problems Chapter 37 - Preparation of Water-Soluble Compounds Through Salt Formation, Pages 747-766, Michael J. Bowker, P. Heinrich Stahl Chapter 38 - Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties, Pages 767-785, Camille G. Wermuth Chapter 39 - Drug Solubilization with Organic Solvents, or Using Micellar Solutions or Other Colloidal Dispersed Systems, Pages 786-812, Michael J. Bowker, P. Heinrich Stahl Chapter 40 - Improvement of Drug Properties by Cyclodextrins, Pages 813-840, Kaneto Uekama, Fumitoshi Hirayama Chapter 41 - Chemical and Physicochemical Approaches to Solve Formulation Problems, Pages 841-853, Camille G. Wermuth Part VIII: Development of New Drugs: Legal and Economic Aspects Chapter 42 - Discover a Drug Substance, Formulate and Develop It to a Product, Pages 855-866, Bruno Galli, Bernard Faller Chapter 43 - Drug Nomenclature, Pages 867-877, R.G. Balocco Mattavelli, J.C. Dong, S. Lasseur, S. Kopp Chapter 44 - Legal Aspects of Product ProtectionWhat a Medicinal Chemist Should Know About Patent Protection, Pages 878-893, Maria Souleau Chapter 45 - The Consumption and Production of Pharmaceuticals, Pages 894-921, Bryan G. Reuben Index, Pages 923-942 http://www.sciencedirect.com/science/book/9780123741943 [ Last edited by leigen on 2008-10-1 at 12:54 ] |
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