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小木虫: 金币+0.5, 给个红包，谢谢回帖
jinqingxian: 金币+10, 多谢 2016-01-03 16:31:01
小木虫: 金币+0.5, 给个红包，谢谢回帖
jinqingxian: 金币+10, 多谢 2016-01-03 16:31:01
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应该是因临床试验效果不好，被原研制方Cortex放弃了 http://www.trademarkia.com/ampakine-77965906.html ABANDONED - NO STATEMENT OF USE FILED 11/5/2012 https://en.wikipedia.org/wiki/CX-516 CX-516 is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator and is being developed by a collaboration of Cortex and Shire and Servier. It was researched as a treatment for Alzheimer's disease under the brand name Ampalex, and was also being examined as a treatment for ADHD. CX-516 was the first ampakine compound developed by Cortex and while it showed good in vitro activity and positive results in animal tests, the human trials proved disappointing due mainly to low potency and short half-life. However, CX-516 is still widely used in animal research into the ampakine drugs and is the standard reference compound that newer, more potent drugs of this class such as farampator and CX-717 are compared to. |
2楼2016-01-03 09:48:42
