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On the basis of the discussion above, it may be concluded that the spinal administration, but not systemic administration, of hemin significantly attenuated the development of nerve injury-induced NP. On the other hand, simultaneous administration of hemin via spinal and systemic routes, as well as CORM-2 alone, produced a more pronounced inhibition of the development of NP, through activation of antiinflammatory and anti-oxidant mechanisms. It suggests that concurrent pharmacological activation of HO-1/CO pathway both at spinal and peripheral sites, but not peripheral site alone, is needed to prevent the development of sciatic nerve CCI-induced neuropathic pain in Wistar rats. 主要的词： the spinal administration systemic administration |
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SUNHONG123
木虫 (正式写手)
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执著追求: 金币+5, ★★★★★最佳答案 2015-12-17 10:08:34
执著追求: 金币+5, ★★★★★最佳答案 2015-12-17 10:08:34
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在上述讨论的基础上,可能会得出这样的结论,脊柱给药，但不是全身系统给药、氯高铁血红素能够显著减弱神经创伤NP的发展。另一方面,通过脊柱和全身路线同时给药氯高铁血红素,或者CORM-2单独给药,通过激活抗炎和抗氧化机制，产生了更加明显的抑制神经性损伤的发展。它表明在脊髓和外围站点HO-1/CO途径的并发的药理性激活,但不是外围站点单独的激活,需要预防在wistar大鼠体内的CCI-引诱的坐骨神经疼痛的发展 。 发自小木虫Android客户端 |
2楼2015-12-17 09:19:40