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On the basis of the discussion above, it may be concluded that the spinal administration, but not systemic administration, of hemin significantly attenuated the development of nerve injury-induced NP. On the other hand, simultaneous administration of hemin via spinal and systemic routes, as well as CORM-2 alone, produced a more pronounced inhibition of the development of NP, through activation of antiinflammatory and anti-oxidant mechanisms. It suggests that concurrent pharmacological activation of HO-1/CO pathway both at spinal and peripheral sites, but not peripheral site alone, is needed to prevent the development of sciatic nerve CCI-induced neuropathic pain in Wistar rats. Ö÷ÒªµÄ´Ê£º the spinal administration systemic administration |
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