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It can be easily seen that this Biginelli condensation conducted smoothly in the PEG1000-DAIL/toluene system and afforded DHPMs in exce-llent yields of 80%―95% within only 10―30 min. Both ace-toacetate and acetoacetone showed high activities. It is of great importance that many of the pharmacologically relevant subs-titution patterns on the aromatic ring could be introduced without any interruption in efficiency. 发自小木虫IOS客户端 |
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