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[交流] CSC 博士招生_英国贝尔法斯特女王大学机械与航空航天学院

Project Title: Green synthesis of novel nanocomposites for biomedical applications

Project Description:

In recent years, there has been increasing application of hydrogel based polymer nanocomposites in biomedical field, such as wound dressings, bone cements, tissue scaffolds, as well as cancer treatment. Nanocomposites combining hydrogel and multi-functional nanoparticles (NPs) have received particular attention, e.g. hydrogel incorporating gold or magnetic iron oxide NPs have been proposed for multi-modality cancer therapies (trauma sensing, pulsed drug delivery, bio-imaging, and hyperthermia).

In previous approaches the hydrogel based nanocomposites have been obtained by sequential mixing of pre-synthesized NPs with hydrogels. These conventional synthesis approaches of NPs are predominantly by chemical reduction (e.g. AuNPs), alkaline precipitation in water, water-in-oil microemulsion, and thermal decomposition (e.g. iron oxide NPs). These methods mostly require harsh chemicals and elevated temperature, and suffer from large NP size distribution, surface contamination by surfactants and toxicity of the organic residues, which present major challenges (limited functionality and potential safety issue) towards clinical applications. In addition, the critical element of a successful nanocomposite - controlled microstructure (NP and matrix) and long term stability (dispersion) is yet to be achieved.

The aim of the proposed project is to develop new knowledge and expertise on a chemical-free in situ green-synthesis composite technology. The project is in collaboration with School of Pharmacy and is supported by a UK leading biomedical company for the development of the novel techniques and materials. The student will have the opportunities to be trained on a wide range of state of the art material synthesis and characterization facilities and the outcome of the proposed project will be NP/hydrogel bio-nanocomposites with low toxicity, high stability and multi-functionality and these materials may demonstrate their potential capability particularly in anti-microbial applications well as other areas such as tissue engineering and drug delivery. Other planned output include conferences presentations and journal publications.

First/Lead Supervisor and their contact details: Dr Dan Sun, d.sun@qub.ac.uk

Second Supervisor and their contact details: Prof Fraser Buchanan, f.buchanan@qub.ac.uk
Prof Brendan Gilmore, b.gilmore@qub.ac.uk

贝尔法斯特女王大学（Queen's University Belfast）于1845年由维多利亚女王建校，因此为女王大学。为英国顶尖名校，全球百强名校。是一所享誉欧洲的公立顶级研究型大学，该校拥有全英国和爱尔兰顶级医学院和工程学院，该校的医学院，商学院，工学院以及管理学院也都在全爱尔兰名列前茅。该大学位于英国的北爱尔兰首府贝尔法斯特，其教研历史悠久，学术成就昭著，是英国和爱尔兰历史最悠久的大学之一，并且也是英国著名的常青藤名校罗素集团大学成员之一。
（https://baike.baidu.com/link?url ... ffxyY6DZ_qrSWrVS8hj）

贝尔法斯特女王大学机械与航空航天学院官网，相关招聘信息详见网站。
https://www.qub.ac.uk/schools/Sc ... rospaceEngineering/
有意愿者可直接发邮件至导师邮箱咨询，一导，二导，三导均可。（建议直接联系一导）

导师简介
Dr Dan Sun, d.sun@qub.ac.uk
https://www.qub.ac.uk/schools/Sc ... emicStaff/DrDanSun/

Prof Fraser Buchanan, f.buchanan@qub.ac.uk
https://www.qub.ac.uk/schools/Sc ... ProfFraserBuchanan/

Prof Brendan Gilmore, b.gilmore@qub.ac.uk

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