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| Monomethyl auristatin E (MMAE) was prepared by replacing a protected form of monomethylvaline for the amino-terminal valine in the synthesis of auristatin EMMAE was then further modified with maleimidocaproyl-valine-citrulline to result in vcMMAE, which contained a p-aminobenzylcarbamate spacer between the MMAE and the linker |
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