| 查看: 1135 | 回复: 4 | ||
chenyimin_2008银虫 (正式写手)
|
[求助]
对甲苯磺酸索拉非尼的理化性质 已有1人参与
|
| 各位有默克索引吗？能否帮我找下对甲苯磺酸的理化性质，谢谢啊！ |
回复此楼» 猜你喜欢
基于AI智能算法的装备结构可靠性分析与优化设计技术
已经有0人回复
-
求助求助
已经有0人回复
-
药理学论文润色/翻译怎么收费?
已经有152人回复
-
农业资源与环境、智慧农业专业本科生毕业论文课题选题求助
已经有1人回复
-
人工智能赋能聚合物及复合材料模型应用与实践
已经有0人回复
-
各国和国际组织现行药典注射用水质量标准
已经有0人回复
-
求助用微谱数据库查询
已经有0人回复
-
计算化学与人工智能驱动的MOFs性能预测与筛选技术
已经有0人回复
-
研三实验求指导
已经有0人回复
-
金属材料多尺度计算模拟技术与应用：微观机理到宏观性能的集成工作
已经有0人回复
-
江西科技师范大学微生物天然药物老师介绍
已经有23人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 对甲苯磺酸索拉非尼质量研究
已经有4人回复
- 交流一下索拉非尼对甲苯磺酸盐的颜色
已经有7人回复
- 求对甲苯磺酸索拉非尼原料药的质量标准！！！！！！！！！！！！！！
已经有2人回复
- 对甲苯磺酸索拉非尼原料药的进口标准
已经有10人回复
- [求助] 对甲苯磺酸索拉非尼和甲氧苄啶的合成
已经有1人回复
- 求助 索拉非尼(Sorafenib,BAY-43-9006)的标准
已经有2人回复
- 【求助】求对甲苯磺酸索拉非尼高效液相的流动相，检测波长，谢谢！！
已经有2人回复
痴夷子皮
版主 (文坛精英)
老痞
- DRDEPI: 8
- 应助: 2016 (讲师)
- 贵宾: 5.368
- 金币: 54487.3
- 散金: 41688
- 红花: 303
- 沙发: 1206
- 帖子: 32611
- 在线: 4303.7小时
- 虫号: 674536
- 注册: 2008-12-14
- 性别: GG
- 专业: 无神论
- 管辖: 人文社科
【答案】应助回帖
感谢参与，应助指数 +1
|
Title: p-Toluenesulfonic Acid CAS Registry Number: 104-15-4 CAS Name: 4-Methylbenzenesulfonic acid Additional Names: tosic acid Molecular Formula: C7H8O3S Molecular Weight: 172.20 Percent Composition: C 48.82%, H 4.68%, O 27.87%, S 18.62% Line Formula: CH3C6H4SO3H Literature References: Prepd by sulfonation of toluene with 96-100% H2SO4; when carried out at 75° the compn of the reaction product is 75% para-, 19% ortho- and 6% meta-toluenesulfonic acid. Convenient lab prepn: L. F. Fieser, Experiments in Organic Chemistry (Boston, 3rd ed., 1955) p 144. The separation of toluene from petroleum fractions can be accomplished by sulfonation with H2SO4 at 60°. Properties: Monoclinic leaflets or prisms. Also reported as crystallizing with 1H2O or 4H2O. When anhydrous, mp 106-107°. Metastable form, mp 38°. bp20 140°. bp0.1 185-187°. Freely sol in water, about 67 g/100 ml. Sol in alc and ether. Melting point: mp 106-107°; mp 38° Boiling point: bp20 140°; bp0.1 185-187° Derivative Type: Sodium salt Molecular Formula: C7H7NaO3S Molecular Weight: 194.18 Percent Composition: C 43.30%, H 3.63%, Na 11.84%, O 24.72%, S 16.51% Properties: Orthorhombic plates, very sol in water. CAUTION: Highly irritating to skin, mucous membranes. Use: In dye chemistry; in manuf of oral antidiabetic drugs. |
2楼2015-11-26 10:14:59
3楼2015-11-26 10:37:26
chenyimin_2008
银虫 (正式写手)
- 应助: 4 (幼儿园)
- 金币: 619.9
- 散金: 67
- 红花: 1
- 帖子: 662
- 在线: 232.6小时
- 虫号: 496292
- 注册: 2008-01-17
- 性别: GG
- 专业: 药物化学
4楼2015-11-26 12:18:12
痴夷子皮
版主 (文坛精英)
老痞
- DRDEPI: 8
- 应助: 2016 (讲师)
- 贵宾: 5.368
- 金币: 54487.3
- 散金: 41688
- 红花: 303
- 沙发: 1206
- 帖子: 32611
- 在线: 4303.7小时
- 虫号: 674536
- 注册: 2008-12-14
- 性别: GG
- 专业: 无神论
- 管辖: 人文社科
|
Title: Sorafenib CAS Registry Number: 284461-73-0 CAS Name: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide Additional Names: N-4-(Chloro-3-(trifluoromethyl)phenyl)-N¢-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea Manufacturers' Codes: Bay-43-9006 Molecular Formula: C21H16ClF3N4O3 Molecular Weight: 464.82 Percent Composition: C 54.26%, H 3.47%, Cl 7.63%, F 12.26%, N 12.05%, O 10.33% Literature References: Multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Prepn: B. Riedl et al., WO 0041698 (2000 to Bayer); eidem, US 03139605 (2003); D. Bankston et al., Org. Process Res. Dev. 6, 777 (2002). Structure-activity study: U. R. Khire et al., Bioorg. Med. Chem. Lett. 14, 783 (2004). Characterization of kinase inhibition: S. M. Wilhelm et al., Cancer Res. 64, 7099 (2004). Mechanism of action study: D. J. Panka et al., Cancer Res. 66, 1611 (2006). LC determn in serum: S. Afify et al., J. Chromatogr. B 809, 99 (2004). Clinical pharmacokinetics: H. Richly et al., Int. J. Clin. Pharmacol. Ther. 41, 620 (2003). Analysis of clinical safety and efficacy: D. Strumberg et al., Eur. J. Cancer 42, 548 (2006). Clinical evaluation and brief review: H. DeGrendele, Clin. Colorectal Cancer 3, 16-18 (2003). Review of clinical development: B. I. Rini, Expert Opin. Pharmacother. 7, 453-461 (2006). Properties: White solid, mp 205.6°. Melting point: mp 205.6° Derivative Type: Tosylate CAS Registry Number: 475207-59-1 Trademarks: Nexavar (Bayer) Molecular Formula: C21H16ClF3N4O3.C7H8O3S Molecular Weight: 637.03 Percent Composition: C 52.79%, H 3.80%, Cl 5.57%, F 8.95%, N 8.80%, O 15.07%, S 5.03% Therap-Cat: Antineoplastic. Keywords: Antineoplastic; Tyrosine Kinase Inhibitors. |
5楼2015-11-26 12:23:21
