| 查看: 1036 | 回复: 1 | |||
| 当前主题已经存档。 | |||
wittyboy至尊木虫 (著名写手)
|
[交流]
请问在色谱分析的方法学评价中Selectivity 和Specificity 区别是什么？
|
||
|
谢谢， 下面是英文解释， 但是我还是没弄清楚具体区别是什么， 尤其是在药物残留方面 The term selectivity is often confused and incorrectly used with the term specificity, especially in the field of chromatographic analytical methods. Selectivity: the selectivity of an assay is a measure of the extent to which the method can determine a parti- cular compound in the analysed matrices without inter- ference from matrix components. A method that is per- fectly selective for an analyte or group of analytes is specific。 Specificity: the validation procedure should confirm the ability of the method to unequivocally assess the ana- lyte in the presence of other components that may be present (for example, impurities, degradation products and matrix components). The necessary validation studies depend on the method’s use. Lack of specificity of an individual analytical procedure may be compen- sated by other supporting analytical procedures [2]. This definition from the International Conference on Harmonization (ICH) is restricted to pharmaceuticals, including active substances and formulations. However, in the fields of bioanalysis (analysis of analytes in bio- logical matrices and in bioavailability studies) the spe- cificity is completely neglected. |
回复此楼» 猜你喜欢
今天系统多次维护，明天很可能放榜！
已经有5人回复
-
欢迎发来filecode的Mz6后的代码验证其规律
已经有74人回复
-
岩土工程学报什么时候才能终审完呐
已经有4人回复
-
时间戳又变了8-15
已经有25人回复
-
2027广东省杰青
已经有6人回复
-
快农历七夕节了，轻松一下，男人悄悄话，女施主请不要进来。
已经有3人回复
-
哪位老哥知道今年的国自然具体哪一天放榜？
已经有9人回复
-
咱们一起用铁证分析2026国家社科基金中标与否
已经有26人回复
-
我的国基提前知道中了，可是同事的操作让我实在接受不了，怎么会有这样的人
已经有16人回复
-
有时候，自然基金真的不能太认真 （我的申报经验）
已经有12人回复
2楼2008-09-14 21:02:57
25