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ÈçÌ⣬¾ä×ÓΪ£º A plot of cumulative percentage less than a stated cut-off diameter versus cut-off diameter should usually be provided. From this, the Mass Median Aerodynamic Diameter (MMAD) and Geometric Standard Deviation (GSD) may be determined, if appropriate Õû¶ÎÓï¾³£¨ÎÞÐè·Ò룬°ïÖúÀí½â£©£ºUsing a multistage impactor or impinger, the drug mass on each stage and the cumulative mass undersize a given stage should be determined rather than the percentage of emitted dose (or other derived parameter) as these can hide variations in delivered dose. A plot of cumulative percentage less than a stated cut-off diameter versus cut-off diameter should usually be provided. From this, the Mass Median Aerodynamic Diameter (MMAD) and Geometric Standard Deviation (GSD) may be determined, if appropriate (in the case of uni-modal log-normal distribution). Mass balance reconciliation should also be considered. |
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