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咖啡卡农金虫 (正式写手)
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[求助]
Silk Nanoparticles概念分不清
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找到一篇文献pH-Dependent Anticancer Drug Release from Silk Nanoparticles，其中 Silk Nanoparticles不明白什么意思。cnki上比较多是解释是丝素纳米颗粒，其英文为silk fibroin nanoparticles，感觉这两个不是一个概念。是不是存在什么丝状纳米颗粒或蚕丝纳米颗粒等等。也查过英文的，多是silk fibroin nanoparticles。不知道二者是否为同一概念，希望专精的前辈给予指点，感激不尽。 以下是摘要部分： Silk has traditionally been used as a suture material because of its excellent mechanical properties and biocompatibility. These properties have led to the development of different silk-based material formats for tissue engineering and regenerative medicine. Although there have been a small number of studies about the use of silk particles for drug delivery, none of these studies have assessed the potential of silk to act as a stimulus-responsive anticancer nanomedicine. This report demonstrates that an acetone precipitation of silk allows the formation of uniform silk nanoparticles (98 nm diameter, polydispersity index 0.109), with an overall negative surface charge (-33.6 +/- 5.8 mV), in a single step. Silk nanoparticles are readily loaded with doxorubicin (40 ng doxorubicin/[mu]g silk) and show pH-dependent release (pH 4.5> 6.0 > 7.4). In vitro studies with human breast cancer cell lines demonstrates that the silk nanoparticles are not cytotoxic (IC50 > 120 [mu]g mL-1) and that doxorubicin-loaded silk nanoparticles are able to overcome drug resistance mechanisms. Live cell fluorescence microscopy studies show endocytic uptake and lysosomal accumulation of silk nanoparticles. In summary, the pH-dependent drug release and lysosomal accumulation of silk nanoparticles demonstrate the ability of drug-loaded silk nanoparticles to serve as a lysosomotropic anticancer nanomedicine. |
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