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Postdoc wanted in University of North Carolina at Chapel Hill, USA
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Postdoctoral Position of Gene Expression and/or Cancer Epigenetics Job Description Lineberger Comprehensive Cancer Center & the Department of Biochemistry & Biophysics University of North Carolina at Chapel Hill (UNC) School of Medicine Postdoctoral position available for highly motivated candidates with a fresh PHD training in molecular & cellular biology or biochemistry to join Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill (UNC) School of Medicine. The lab emphasizes on mechanistic understandings of gene regulation, chromatin, and human disease, notably cancer. Related publications- Chi P, Allis CD and Wang GG. Covalent histone modifications: mis-written, mis-erased and mis-interpreted in human cancers. Nat Rev Cancer. 2010,10(7):457-69. Cai L, Rothbart SB, Lu R, Xu B, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J, Wang GG. An H3K36 methylation engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol Cell. 2013 Feb 7;49(3):571-82. Gough SM, Lee F, Yang F, Walker RL, Zhu YJ, Pineda M, Onozawa M, Chung YJ, Bilke S, Wagner EK, Denu JM, Ning Y, Xu B, Wang GG, Meltzer PS, Aplan PD. NUP98-PHF23 is a chromatin modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD domain histone reader function. Cancer Discovery. 2014 Feb 17. [Epub ahead of print] PMID: 24535671 Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, Zheng D, Jin J, Wang GG. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood. 2015 Jan 8;125(2):346-57. Zhang Z, Rothbart SB, Allison DF, Cai Q, Wang Y, Strahl BD, Wang GG, Song J. An allosteric interaction links USP7 to deubiquitination and chromatin targeting of UHRF1. Cell Reports (in press) Xu B, Konze KD, Jin J, Wang GG. Targeting EZH2 and PRC2 dependence as novel anti-cancer therapy. Exp Hematol. 2015 Aug;43(8):698-712. PMID: 26027790 Webpage- http://www.med.unc.edu/biochem/people/faculty/primary/wang Applicants should be self-motivated with a strong background, laboratory and analytical skills, as well as a track record of publication. Full applications including CV, a cover letter (with summary of research experiences, accomplishments and future interests, and expected availability date) reprints of publications, and contact information of three referees should be submitted to e-mail: gregwang.unc@gmail.com |
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2015-10-14 12:31:12, 123.5 K
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