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[资源] Cell：最值得关注的CRISPR论文 TOP10

在过去的两年里，与CRISPR相关的论文超出了650篇，包括通过基因编辑（基因敲除、敲入、抑制、激活）创造具有特定特征或者疾病的动物模型以及在细胞、受精卵中应用CRISPR等。在疾病治疗领域的应用涉及了HIV、疟疾、癌症、肌肉萎缩症等，这些进展都是令人震惊的。

以下就是在这期合集中涉及的10篇论文：

序号论文题目
1 Development And Applications Of CRISPR-Cas9 For Genome Engineering
2 To Acquire Or Resist: The Complex Biological Effects Of CRISPR-Cas Systems
3 CRISPR-Cas Systems: Prokaryotes Upgrade To Adaptive Immunity
4 Crystal Structure Of Cas9 In Complex With Guide RNA And Target DNA
5 CRISPR-Mediated Modular RNA-Guided Regulation Of Transcription In Eukaryotes
6 One-Step Generation Of Mice Carrying Reporter And Conditional Alleles By Crispr/Cas-Mediated Genome Engineering
7 Generation Of Gene-Modified Cynomolgus Monkey Via Cas9/RNA-Mediated Gene Targeting In One-Cell Embryos
8 Dynamic Imaging Of Genomic Loci In Living Human Cells By An Optimized CRISPR/Cas System
9 Highly Efficient Targeted Mutagenesis Of Drosophila With The CRISPR/Cas9 System
10 An iCRISPR Platform For Rapid, Multiplexable, And Inducible Genome Editing In Human Pluripotent Stem Cells
（附加几篇中文介绍的几篇科普）

链接：http://pan.baidu.com/s/1bnocq2j 密码：nsob

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