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1 In the recent past, in our laboratory, ascorbyl palmitate (ASP) vesicles (aspasomes) were prepared and studied for permeation-enhancing properties (Gopinath et al., 2004) and their utility as a carrier for drug targeting to brain in mice was also demonstrated (unpublished data). 2 However, no attempt has been made to address the utility of antioxidant in targeting tumor tissue. The prevalence of leaky vascular endothelium at the tumor tissue allows the extravasation of the long-circulating liposomes loaded with an antiox |
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1 In the recent past, in our laboratory, ascorbyl palmitate (ASP) vesicles (aspasomes) were prepared and studied for permeation-enhancing properties (Gopinath et al., 2004) and their utility as a carrier for drug targeting to brain in mice was also demonstrated (unpublished data). 1½üÆÚ£¬ÎÒʵÑéÊҳɹ¦ÖƱ¸ÁË¿¹»µÑªËáרéµËáõ¥ÄÒÅÝ£¬²¢Ñо¿ÁËÆä¼ÓÇ¿ÐÍÉøÍ¸ÐÔÄÜ¡££¨GopinathµÈÈË2004ÄêµÄÑо¿£©£¬Í¬Ê±¸ù¾Ýδ·¢±íÑо¿Ö¤Êµ£¬¸Ã¿¹»µÑªËáרéµËáõ¥ÄÒÅÝ¿É×÷ÎªÔØÌ壬°ÐÏò¸øÒ©ÖÁʵÑéÊó´óÄÔ¡£ 2 However, no attempt has been made to address the utility of antioxidant in targeting tumor tissue. The prevalence of leaky vascular endothelium at the tumor tissue allows the extravasation of the long-circulating liposomes loaded with an antiox È»¶ø£¬ Ŀǰ»¹Ã»ÓÐÈκÎʵÑéÖ¤Ã÷£¨¸ÃÎïÖʵģ©£¬ÔÚ¶¨Ïò¸øÒ©Ö×Áö×é֯ʱµÄ¿¹Ñõ»¯¼Á¹¦Ð§¡£Ö×Áö×éÖ¯ÖУ¬Ñª¹ÜÄÚÆ¤·¢ÉúÆÆÂ©£¬Ê¹µÃ´øÓп¹Ñõ»¯¹¦Äܵij¤Ñ»·Ö¬ÖÊÌåÒç³ö¡£ |
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3Â¥2015-09-18 15:18:10
sundy93
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4Â¥2015-09-18 18:08:21
sundy93
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5Â¥2015-09-18 18:08:44











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