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[交流] FDA QSAR Toxicity Models Now Available

http://www.leadscope.com/fda_qsar_models/

Columbus, Ohio August 26, 2008 – Leadscope announces the availability of the Leadscope FDA QSAR Toxicity Models.

Leadscope is making the FDA QSAR Toxicity Models available through a Cooperative Research & Development Agreement with the U.S. Food & Drug Administration (FDA). These models allow scientists to predict the potential toxicity and adverse human clinical effects of pharmaceuticals, cosmetics, food ingredients and other chemicals.

The Models are constructed by FDA scientists based on both proprietary and non-proprietary data. Leadscope technology allows delivery of models without disclosing any training sets.

The FDA QSAR Toxicity Models will be distributed via annual licenses in Suites containing multiple models relative to specific biological endpoints.  The following Suites are now available:

Toxicity Endpoints                                                       Human Clinical Endpoints
▪ Rodent Carcinogenicity                                           ▪ Cardiological Adverse Effects
▪ Genetic Toxicity                                                       ▪ Hepatobiliary Adverse Effects
▪ Reproductive Toxicity                                              ▪ Urinary Tract Adverse Effects
▪ Developmental Toxicity
▪ Neurotoxicity
▪ Misc. Toxicity Endpoints

A scientist may enter a single compound or a batch of compounds and receive predictions across multiple endpoints.  The FDA QSAR Toxicity Models are a stand-alone product not requiring any other software or training.

Loftus Lucas, Leadscope’s CEO, said, “The release of these FDA QSAR Toxicity Models culminates several years of work with the FDA to bring their toxicity data to scientists in an easy to use system.  Scientists will get the same prediction from these Models as an FDA Regulator”.

The FDA Center for Drug Evaluation and Research (CDER) Informatics and Computational Safety Analysis Staff (ICSAS) and Leadscope are pleased to host a symposium on the use of Leadscope software with FDA databases for QSAR computational toxicology safety analysis at the FDA, other U.S. government agencies and international regulatory bodies.  The all-day meeting will be held on September 17, 2008 at the new FDA White Oak Campus in Silver Spring, Maryland.  This symposium is free and open to the public.  To view the agenda visit www.leadscope.com/fda_symposium.php.  Registration is required.  Please RSVP by September 12, 2008, at info@leadscope.com.

To view the FDA QSAR Model Suites visit Leadscope’s website at www.leadscope.com/fda_qsar_models.  For further information or to request on-line demonstration with a Leadscope scientist, contact us at info@leadscope.com.

Loftus Lucas
Leadscope, Inc.

1393 Dublin Road
Columbus, Ohio 43215
Phone: 614-599-2700
Fax:  614-675-3732

info@leadscope.com

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