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[求助]
楼主非生物专业,现在需要翻译生物文献一段,求助啊 已有1人参与
The glucose tolerance curve is generally characteristic of an increased tolerance if the test is modified: (1) the dog is on a standard carbohydrate diet for 3 days; (2) the intravenous test is used, and, most important; (3) blood sampling is continued for 6 to 8 hours. A prolongation of the hypoglycemic phase (phase III, Fig. 3-12 ) is the most significant portion of the curve. A dog with a tendency toward persistent hypoglycemia is likely to have an abnormal response in the insulin tolerance test, but this is not a reliable test of insulinoma. The tolerance curve may have a minimal drop in blood glucose and remain below the original level for a prolonged length of time. Therefore, the curve has “ insulin resistance ” and “ h ypoglycemia unresponsiveness. ” Use of this test carries some risk for a hypoglycemic crisis, so a glucose solution for intravenous administration should be at hand. Similarly, the glucagon stimulation test has not been a reliable test for hyperinsulinism. T he hypoglycemia that follows oral administration of leucine in children has been used in human patients with islet cell tumors. Marked hypoglycemia occurs within 30 to 60 min after L-leucine administration. Leucine-induced hypoglycemia is also associated with a rise in plasma insulin. In patients with islet cell tumors, leucine sensitivity disappeared after surgical excision of the tumor, which indicates that the tumorous islet cells alone were being stimulated by the leucine. This test has been used successfully in pancreatic islet cell tumors of dogs. Currently, the most useful tests are the serum insulin and the fasting plasma glucose taken as described earlier. There is an inappropriately high level of insulin ( 20 μ U/l) with a hypoglycemia of
3mmol/l ( 55mgn). |
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