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The accessibility to • OH attack on the H atoms at the fi ve carbons varies as calculated using a Monte-Carlo simulation and the RADACK procedure, and by an ab initio study. Reduced strand breakage occurred in sequences exhibiting low accessibility of H4 ′ and H5 ′ 2, leading to a low probability of abstraction by • OH due to a narrow, minor groove. |
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baoshanqiu
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