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[交流] 西安交通大学赵四海副教授欢迎有冲劲的年轻学子报考(病理学与病理生理学硕博生)

欢迎有志于基础医学的年轻学子报考病理学与病理生理学硕博生,推免和统考均可。
如果您初生牛犊不怕虎,如果您为了理想热血沸腾,如果您经历风雨仍保持一颗向前的心,如果您还有童年依稀的科学梦,如果你是一个敢于吃苦的人,那么我欢迎您到我这里来。我们实验室不是校内最好的,我的水平也不是国内顶尖的,但是我是最喜欢和学生做朋友的。在这里,我们有困难共同克服,有成果我愿意和你一起分享,如果需要也可让你独享。我需要的是亦师亦友的学生,不是唯命是从的随从。如果你是这样的人,那么请来吧!

联系方式: E-mail:  sihaizhao@mail.xjtu.edu.cn

电话:029-82655363 82655348 传真:029-82655362


赵四海,男,35岁,医学博士,副教授,生物学博士后(出站),病理学与病理生理学硕士生导师(2016博士也可以),陕西省科技新星,西安交通大学优秀博士后,陕西省实验动物学会副秘书长。曾赴日本山梨大学短期进修,在国内外杂志发表论文72篇,其中SCI收录48篇(第一/通讯作者27篇),MI收录6篇。获得陕西省高等学校科技进步奖1项(第一完成人),中国实验动物学会优秀青年人才奖1项,中国实验动物学会科学技术二等奖1项(第二完成人)。
主持国家自然科学基金2项(30900526,81370379),中央高校基本科研业务费专项资金-青年教师跟踪支持项目(优青培育类)1项,博士后基金2项(其中特别资助一项),陕西省科技项目2项,西安交通大学基金3项,参与863项目、国家自然科学基金和陕西省重大科技项目多项。

(1)国家自然科学基金(81370379):利用基因敲除家兔研究salusins影响动脉粥样硬化发生发展的机制, 90万元, 2014-01-01至2017-12-31。
(2)国家自然科学基金(30900526):利用转基因兔研究 urotensin II 过表达影响动脉粥样硬化进程的分子机制,21万元, 2010-01-01至2012-12-31。
(3)博士后科学基金(20100471616):UⅡ/UT在动脉粥样硬化病变中的分布、表达变化和生物学功能研究,3万元, 2010-03至2012-12-03。
(4)博士后科学基金特别资助(201104669):体内输注尾加压素Ⅱ对动脉粥样硬化形成进程影响的分子机制研究,10万元,2011,09-2013,08。
(5)陕西省科技新星项目(2012KJXX-07):在体内输salusin-α对动脉粥样硬化发生发展影响的分子机制研究,10万元,2012,07-2015,06。
教育、工作经历及获得的荣誉:
2003年毕业于青海医学院(现青海大学医学院)。
2003年起在西安交通大学连续攻读硕士和博士学位,获得过特别优秀研究生唐文治奖学金和优秀毕业生称号。
2007年获得日本动脉粥样硬化学会优秀外国青年学者奖。
2009年获西安交通大学医学博士学位,留校任教。
2009年进入医学院生物学博士后工作站从事科研工作。
2009和2010年度被医学院授予科研优秀奖。
2012年获西安交通大学优秀博士后称号。
2012年被评为陕西省科技新星。
2013年获陕西省高等学校科技进步奖(第一完成人)。
2014年获评中国实验动物学会优秀青年人才和科学技术进步二等奖(第二完成人)。
主要研究方向:
(1)动脉粥样硬化形成的分子机制
(2)抗心血管病药物的研究
(3)转基因动物模型的开发
(4)肝病的循证医学分析研究


近年发表的论文:
1.    Yingfeng An, Shoucui Gao, Daxin Cheng, Xiaojing Wang, Liang Bai, Enqi Liu, Yonglie Chu, Sihai Zhao*. Peginterferon and Chinese herbs exert a combinatorial effect in HBeAg-positive chronic hepatitis B. The Journal of Infection in Developing Countries. 2015. Accepted. (* 通讯作者)
2.    Wang C, Li Y, Gao S, Cheng D, Zhao S*, Liu E*. Breviscapine Injection Improves the Therapeutic Effect of Western Medicine on Angina Pectoris Patients. PLoS One. 2015;10(6):e0129969. (* 通讯作者)
3.    Cheng D, Wang Y, Gao S, Wang X, Sun W, Bai L, Cheng G, Chu Y, Zhao S* and Liu E*. Atorvastatin delays the glucose clearance rate in hypercholesterolemic rabbits. Biomed Pharmacother. 2015;72:24-29. (* 通讯作者)
4.    Li Y, Gao S, An Y, Liu E, Zhao S*. High dose atorvastatin therapy yields a better carotid atherosclerosis improvement in Chinese patients. Int J Cardiol. 2015;185:131-132. (* 通讯作者)
5.    Huifeng Zhang, Si Guo, Liancai Wang, Yadong Dong, Guanjin Tian, Senmao Mu, Deyu Li, Haibo Yu*, Sihai Zhao*. Single-incision laparoscopic splenectomy should be a safe and effective minimally invasive operation as standard laparoscopic splenectomy. Hepato-Gastroenterology. 2014. Accepted. (* 通讯作者)
6.    Haibo Yu, Si Guo, Liancai Wang, Yadong Dong, Guanjin Tian, Senmao Mu, Huifeng Zhang, Deyu Li*, Sihai Zhao*. Laparoscopic splenectomy and esophagogastric devascularization for liver cirrhosis and portal hypertension should be a safe, effective, minimally invasive operation. Hepato-Gastroenterology. 2014. Accepted. (* 通讯作者)
7.    Cheng D, Liu E, Chu Y, Gao S, An Y, Bai L, Wu M, Cheng G, Zhao S*. Interferon plus Oxymatrine Achieved Higher Sustained Virological Response than Interferon Alone in Chronic Hepatitis C. Hepato-Gastroenterology. 2014. Accepted. (* 通讯作者)
8.    Li Y, Zhao S*,Wang Y, Chen Y, Lin Y, Zhu N, Zheng H, Wu M, Cheng D, Lin Y, Bai L, Fan J, and Liu E*. Urotensin II promotes atherosclerosis in cholesterol-fed rabbits. PLoS One. 2014;9(4):e95089.(* 通讯作者)
9.    Cheng D, Liu E, Li Y, Liu R, Bai L, Chen Y, Wang Y, Chu Y, Wu M, Cheng G, Zhao S*. Peginterferon Plus Chinese Herbal Therapy is Associated with a Higher Virological Response than only Peginterferon Therapy in Chronic Hepatitis C. Eur J Clin Microbiol Infect Dis. 2014,33(3):433-438. (* 通讯作者)
10.   Zhao S, Liu Enqi, Cheng D, Li Y, Wang Y, Chen Y, Sun W,  Yan X, Dang S. Comparison of entecavir and adefovir for the treatment of chronic hepatitis B. Braz J Infect Dis. 2012;16(4):366-72. (* 通讯作者)
11.   Zhang G, Wei K, Liu E, Wang Yi, Li Y, Yu Q, Chen Y, Huang B, Lu S, Yan X, Zhao S*. The effects of rosiglitazone on fatty liver of high fat and cholesterol-fed rabbits. J Anim Vet Adv. 2012;(11)14:2564-2569 .(* 通讯作者)
12.   Yu Q, Liu E, Zhao S*, Li Y, Wang Y, Wei K, Huang B, Chen Y, Fan J, Yang P. Association of TaqIB Polymorphism of Cholesteryl Ester Transfer Protein and Coronary Artery Disease in Chinese Population. J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2012 13(5):342-347.
13.   Zhao S*, Liu E, Wei K, Lu S, Chu Y, Li Y, Wang Y, Huang B, Chen Y, Yang P. Interferon plus Chinese herbs are associated with higher sustained virological response than interferon alone in chronic Hepatitis C: a meta-analysis of randomised trials. Antiviral Res. 2011,89(2):156-164. (* 通讯作者)
14.   Zhao S*, Liu E, Wei K, Wang Y, Li Y, Huang B, Chen Y, Yang P. Treatment with peginterferon versus interferon in Chinese patients with chronic hepatitis C. Eur J Clin Microbiol Infect Dis. 2011,30(1):51-57. (* 通讯作者)
15.   Yu H, Zhang H*, Li D, Zhang X, Xue H, Zhao S*. Matrine inhibits matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. Journal of Asian Natural Products Research. 2011. 3(13): 242–250. (* 通讯作者)
16.   Zhao S, Wei K, Yu Q, li Y, cheng F, Wang Y, Yang P, Fan J, liu E. General topic: applications of transgenic rabbits in biomedical research - based on literature search. World Rabbit Science. 2010,18(3):159-167.
17.   Zhao S*, Liu E, Chen P, Cheng D, Lu S, Yu Q, Wang Y, Wei K, Yang P. A Comparison of Peginterferon α-2a and Peginterferon α-2b for Patients With Treatment-Naive Chronic Hepatitis C: A Meta-Analysis of Randomized Trials. Clinical therapeutics,2010, 32 (9):1565-1577. (* 通讯作者)
18.   Yu H, Liu E, Lu S, Zhao S*. Treatment with peginterferon versus interferon in Chinese patients with hepatitis B. Biomed Pharmacother. 2010,64 (10) 559–564. (* 通讯作者)
19.   Yu H, Zhang H*, Zhang X, Li D, Xue H, Pan C, Zhao S*. Resveratrol Inhibits VEGF Expression of Human Hepatocellular Carcinoma Cells through a NF-kappa B-mediated Mechanism. Hepato-Gastroenterology. 2010; 57:1241-1246. (* 通讯作者)
20.   Zhao S, Chu Y, Cheng D, Waqar A, Yu Q, Yang P, Xue X, Yang H. Liu E.   Treatment with peginterferon plus ribavirin versus interferon plus ribavirin for 48 weeks in Chinese patients with chronic hepatitis C. Int J Clin Pract.2009,63(9):1334-1339.
21.   Zhao S, Xun M, Chu Y, Zhu T, Wang Y, Yan L, Xue X, Xu K, Song J, Shao M. Proteome analysis identifies the role of heat stress in production of progeny HCV in Huh7 cells harboring intact HCV. Intervirology. 2008,51(3):196-202.
22.   Zhao S, Xun M, Chu Y, Zhu T, Xue X, Xu K, Song J, Shao M. Comparative Proteomics Analysis of Huh7 Cells Harboring Intact HCV. Chemical Journal of Chinese Universities (Chinese Edition). 2008,29(11)2174-2177.
23.   Zhao S, Cheng D, Liu E, Yu H, Yang H, Xue X, Chu Y. Peginterferon vs. interferon in the treatment of different HCV genotype infections in HIV patients. European Journal of Clinical Microbiology & Infectious Diseases. 2008, 27 (12):1183–1192.
24.   Zhao S, Zhang C, Lin Y, Yang P, Yu Q, Yang P, Chu Y, Fan J, Liu E. The effects of rosiglitazone on aortic atherosclerosis of cholesterol-fed rabbits. Thrombosis Research. 2008,123(2):281-287.
25.   Zhao S, Liu E, Yu H, Yang H, Xun M, Xue X, Song J, Xu K, Chu Y. Comparison of peginterferon and interferon in treating Chinese patients with chronic hepatitis C. Hepato-gastroenterology. 2008;55(84):1047-1054.
26.   Zhao S, Chu Y, Zhang C, Lin Y, Xu K, Yang P, Fan J, Liu E. Diet-induced central obesity and insulin resistance in rabbits. J Anim Physiol Anim Nutr (Berl). 2008;92(1):105-111.
27.   Zhao S, Liu E, Chu Y, Zheng H, Kitajima S, Morimoto M. Numbers of  publications related to laboratory animals. Scandinavian Journal of Laboratory Animal Science. 2007; 34(2):81-86.
28.   Chen Y, Zhao S, Wang Y, Li Y, Bai L, Liu R, Fan J, Liu E. Homocysteine reduces protein S-nitrosylation in endothelium. Int J Mol Med. 2014 Nov;34(5):1277-85.
29.   Wang Y, Bai L, Lin Y, Guan H, Zhu N, Chen Y, Li Y, Gao S, Zhao S, Fan J, Liu E. Demonstration of an add-on effect of probucol and cilostazol on the statin-induced anti-atherogenic effects. Histol Histopathol. 2014;29(12):1593-600.
30.   Chen Y, Zhao S, Huang B, Wang Y, Li Y, Waqar AB, Liu R, Bai L, Fan J, Liu E. Probucol and cilostazol exert a combinatorial anti-atherogenic effect in cholesterol-fed rabbits. Thromb Res. 2013;132(5):565-71.
31.   Wang Y, Zhao S, Bai L, Fan J, Liu E. Expression systems and species used for transgenic animal bioreactors. BioMed Research International. 2013;2013:580463
32.   Zhang R, Yan JD, Valenzuela RK, Lu SM, Du XY, Zhong B, Ren J, Zhao SH, Gao CG, Wang L, Guo TW, Ma J. Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706. Schizophr Res. 2012;141(1):40-7.
33.   Yulong Chen, Zhongdong Wang, Guangwei Zhang, Wei Fan, Yuanqing Tao, Xue He, Sihai Zhao, Bingqiao Huang, Jianglin Fan, Kitajima Shuji, Enqi Liu. Genetic characterization of four wild species of Chinese marmots using microsatellite markers. Biologia. 2012. 67(5):1013-1017.
34.   Wang Y, Cheng F, Chen Y, Li Y, Zhao S, Yu Q, Fan J, Liu E*. High-Dose Rosiglitazone is Pro-atherogenic in Cholesterol-fed Rabbits. Atherosclerosis. 2012,222(1):292-4.
35.   Li Y, Wang Z, Tao Y, Fan W, Li M, Huang B, Zhao S, Fan J, Liu E*.  Characteristics of Himalayan Marmots and their response to an atherogenic diet. Exp Anim. 2012;61(4):461-6.
36.   Yu Q, Li Y, Wang Y, Yu Y, Zhao S, Chen Y, Waqar AB, Fan J, Liu E*. Expression of TRPV1 in rabbits and consuming hot pepper affects its body weight. Mol Biol Rep. 2012 Jul;39(7):7583-9.
37.   Yu Q, Li Y, Waqar AB, Wang Y, Huang B, Chen Y, Zhao S, Yang P, Fan J, Liu E*. Temporal and quantitative analysis of atherosclerotic lesions in diet-induced hypercholesterolemic rabbits. J Biomed Biotechnol. 2012:506159.
38.   Yu Q, Li Y, Wang Y, Zhao S, Yang P, Chen Y, Fan J, and Liu E. C-reactive protein levels are associated with the progression of atherosclerotic lesions in rabbits. Histology and Histopathology. Histol Histopathol. 2012,27(4): 529-535.
39.   Yu Q, Lin Y, Yang P, Wang Y, Zhao S, Yang P, Fan J, Liu E. C-reactive protein is associated with the progression of acute embolic stroke in rabbit model. J Thromb Thrombolysis. 2012,33(4):301-7.
40.   Dang S, Wang W, Wang X, Li Y, Li M, Jia X, Wang Y, Liu E and Zhao S. Telaprevir for Chronic Hepatitis C with Genotype 1: A Meta-Analysis. Hepato-Gastroenterology. 2012.59(114):461-8.
41.   Yu H, Li D, Zhang H, Xue H, Pan C, Zhao S. Effects of ANGPTL3 antisense oligodeoxynucleotides transfection on the cell growths and invasion of human hepatocellular carcinoma cells. Hepato-Gastroenterology. 2011.58(110-111):1742-6.
42.   Sun W, Lei C, Zhao S, Wang L, Bi C, Wang R, Zhou X, Liu E and Chen M. Histomorphological and Ultrastructural Changes of Retinopathy in Diabetic Rabbit Model. J Anim Vet Adv. 2011,10(2):133-137.
43.   Li Y, Wang Y, Yu Q, Wei K, Li M, Zhao S, Kurabayasgi Y, Fan J and Liu E. Compound Danshen dripping pills for stable angina: Meta-analysis of randomized controlled trials. Journal of Medicinal Plants Research. 2011,5(11):2245–2251.
44.   Yu H, Li D, Zhang H, Xue H, Pan C, Zhao S, Wang L. Resveratrol Inhibits Invasion and Metastasis of Hepatocellular Carcinoma Cells. J Anim Vet Adv. 2010,9(24):3117-3124.
45.   Li Y, Kurabayashi Y, Zhao S, Yu Q, Cheng F, Wang Y, Wei K, Liu E. Meta analysis on acupuncture treatment of aphasia. Zhen Ci Yan Jiu. 2010,35(6):468-473.
46.   Chen P, Zhao S, Chu Y, Xu K, Zhua L, Wu Y, Song J, Cao C, Xue X and Niu Y. Anticancer activity of PDSS2, prenyl diphosphate synthase, subunit 2, in gastric cancer tissue and the SGC7901 cell line. Anticancer Drugs. 2009,20(2):141-148.
47.   Yu Q, Han W, Wang Y, Wei K, Zhao S, Yang P, Liu E. How effective use Hirsch index to assess a journal? A study of evaluation the Hirsch index of Chinese Medical Journal. J Anim Vet Adv. 2009,8(12):2485-2488.
48.   Yu H, Pan C, Zhao S, Wang Z, Zhang H, Wu W. Resveratrol inhibits tumor necrosis factor-a-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. Biomed Pharmacother, 2008,62(6):366- 372.
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