| 查看: 50 | 回复: 0 | ||
| 当前主题已经存档。 | ||
[资源]
Adaptive Design Methods in Clinical Trials (Biostatistics)
|
||
|
Adaptive Design Methods in Clinical Trials (Biostatistics) By Shein-Chung Chow, Mark Chang Publisher: Chapman & Hall/CRC Number Of Pages: 296 Publication Date: 2006-11-16 ISBN-10 / ASIN: 1584887761 ISBN-13 / EAN: 9781584887768 Binding: Hardcover Although adaptive design methods are flexible and useful in clinical research, little or no regulatory guidelines are available. One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis that pertain to adaptations made to trial or statistical procedures that are based on accrued data of ongoing clinical trials. The book also offers a well-balanced summary of current regulatory perspectives and recently developed statistical methods in this area. After an introduction to basic concepts and statistical considerations of adaptive design methods, the book questions the impact on target patient populations as the result of protocol amendments and discusses the generalization of statistical inference. The authors also present various adaptive design methods, including where hypotheses are modified during the conduct of clinical trials, for dose selection, and commonly used adaptive group sequential design methods in clinical trials. Following a discussion of blind procedures for sample size re-estimation, the book describes statistical tests for seamless phase II/III adaptive designs and statistical inference for switching adaptively from one treatment to another. The book concludes with computer simulations and various case studies of clinical trials. By providing theoretical and computer simulation results, method comparisons, and practical guidelines for choosing an optimal design, Adaptive Design Methods in Clinical Trials fills the need for a unified, comprehensive, and updated resource in the clinical research and development of adaptive design and analysis. http://ifile.it/fuo5lxj/ |
» 猜你喜欢
材料求调剂 一志愿哈工大总分298分,前三科223分
已经有5人回复
085600 286分 材料求调剂
已经有6人回复
086502化学工程342求调剂
已经有4人回复
材料求调剂一志愿哈工大324
已经有7人回复
328求调剂
已经有7人回复
340求调剂
已经有5人回复
一志愿南昌大学324求调剂
已经有4人回复
求调剂推荐 材料 304
已经有15人回复
291求调剂
已经有19人回复
331环境科学与工程求调剂
已经有3人回复














回复此楼