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Purpose  
The efficacy and safety of venlafaxine in the treatment of depression were  analyzed systematically based on Meta analysis method.
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2Â¥2015-05-20 16:01:50
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Purpose
The efficacy and safety of venlafaxine in the treatment of depression were  analyzed systematically based on Meta analysis method.
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Method
For collecting and summarizing the experimental datas of both English and Chinese literatures with high-quality, which were scored by using Jadad grade standard and  strictly following the integration and elimination standard of literature , the  computer database service systems, such as CNKI, VIP,CMBdisc, Wan- fang database and PubMed, were used to search  literatures in the past decade(namely, retrieval time limitation was 2005-2015 ) that were related to venlafaxine and other anti-depression medication to random contrastive analyze the curative effects and adverse reactions of its alone use. And the  experimental datas  were analyzed with Meta based on RevMan5.0 software.
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Results
25 randomized controlled studies were  identified finally, including 22 China studies and 6 English studies. The results of the effectiveness integrated evaluation of Chinese literatures about venlafaxine in the treatment of depression showed that venlafaxine was superior to other anti-depression medication, which indicated it has statistical significance. The same results were also obtianed by the analysis of English literatures. Combine the results of both  Chinese and  English literatures, it was proved to has statistical significance.
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3Â¥2015-05-20 16:56:32
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haioou: ½ð±Ò+40, ·­ÒëEPI+1, ¡ï¡ï¡ïºÜÓаïÖú 2015-05-23 14:42:57
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The security Meta  analysis showed that the common clinical symptoms were weight gain, blurred vision,constipation,tachycardia, electrocardiographic abnormality, exhaustion,rapid pulse and general malaise, the P values of merged effect of those symptoms were less than 0.05£¬RR<1. The forest graph showed that diamond pattern was  located at the left side of perpendicular line, separated with invalid line phase. compared with other anti-depression medication, venlafaxine has more serious bad reaction to palpitation, nausea and appetite degression.
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The overall analysis of common adverse reactions showed that venlafaxine  was relatively safe with adverse reaction were slighter, compared with  other anti-depression medication.
Conclusion
venlafaxine has better efficacy and more safe and reliable compared with  other anti-depression medication.
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