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[资源] 2008年新书 Organocatalysis

Organocatalysis (Ernst Schering Foundation Symposium Proceedings)
By Manfred Reetz, Benjamin List, Stefan Jaroch, Hilmar Weinmann

Publisher: Springer
Number Of Pages: 342
Publication Date: 2008-07-01
ISBN-10 / ASIN: 3540734945
ISBN-13 / EAN: 9783540734949
Binding: Hardcover

New Concepts for Organocatalysis
S.C. Pan, B. List . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Biomimetic Organocatalytic C–C-Bond Formations
D. Enders, M.R.M. Hüttl, O. Niemeier . . . . . . . . . . . . . . 45
Organocatalytic Syntheses of Bioactive Natural Products
M. Christmann . . . . . . . . . . . . . . . . . . . . . . . . . . 125
Asymmetric Organocatalysis on a Technical Scale:
Current Status and Future Challenges
H. Gröger . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Nucleophilic Carbenes as Organocatalysts
F. Glorius, K. Hirano . . . . . . . . . . . . . . . . . . . . . . . 159
N-HeterocyclicCarbenes: Organocatalysts Displaying
Diverse Modes of Action
K. Zeitler . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183
New Developments in Enantioselective Brønsted Acid Catalysis:
Chiral Ion Pair Catalysis and Beyond
M. Rueping, E. Sugiono . . . . . . . . . . . . . . . . . . . . . . 207
Chiral Organocatalysts for Enantioselective
Photochemical Reactions
S. Breitenlechner, P. Selig, T. Bach . . . . . . . . . . . . . . . . 255
Organocatalysis by Hydrogen Bonding Networks
A. Berkessel . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
Recoverable, Soluble Polymer-Supported Organic Catalysts
M. Benaglia . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299
Controlling the Selectivity and Stability of Proteins
by New Strategies in Directed Evolution:
The Case of Organocatalytic Enzymes
M.T. Reetz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321

Chemical synthesis is one of the key technologies underlying modern drug discovery and development. For the design and accessibility of novel structures and the rapid preparation of new test compounds and development candidates with often highly complex chemical architecture, it is essential to use state-of-the-art chemical synthesis technologies. Recent developments in the field of asymmetric catalysis point to a third class of catalysts besides the established enzymes and metal complexes, so-called organocatalysts. These low-molecular-weight, organic molecules enable highly chemo- and stereoselective chemical transformations for the rapid assembly of complex bioactive molecules of interest for the pharmaceutical industry.

This book presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It illustrates current progress in organocatalysis in functional group interconversions, organocatalytic CC- and CX-bond formations with small molecules as well as peptide-based catalysts and genetically engineered enzymes and their applications in natural product and drug syntheses. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state of the art, current trends and perspectives in this highly dynamic field of research.

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[ Last edited by nxl5096224 on 2009-1-4 at 18:55 ]

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