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《药代动力学和毒代动力学》2015最新书籍
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书名 PHARMACOKINETICS AND TOXICOKINETICS 作者businessMEHDI BOROUJERDICollege of Health Sciences – School of PharmacyUniversity of Massachusetts LowellLowell, 页数538 出版社CRC press International Standard Book Number-13: 978-1-4822-2135-0 (eBook - PDF) Preface............................................................................................................................................xix Chapter 1 The Influence of Routes of Administration on ADME.................................................1 1.1 Introduction........................................................................................................1 1.2 Pharmacokinetics (PK) and Pharmacodynamics (PD)......................................1 1.3 Toxicokinetics (TK) and Toxicodynamics (TD)................................................2 1.4 Concepts Basic to PK and TK............................................................................4 1.5 Routes of Exposure/Administration...................................................................4 1.5.1 First Category........................................................................................5 1.5.1.1 Gastrointestinal Site of Absorption.......................................5 1.5.1.2 Sublingual and Buccal Absorption........................................5 1.5.1.3 Pulmonary Route of Administration and Absorption...........9 1.5.1.4 Subcutaneous Absorption.................................................... 19 1.5.1.5 Intramuscular Route of Administration and Absorption.....22 1.5.1.6 Intraperitoneal Administration of Drugs.............................25 1.5.1.7 Rectal Route of Administration...........................................29 1.5.1.8 Intravaginal Route of Administration.................................. 31 1.5.2 Second Category: Parenteral Routes of Administration..................... 31 1.5.2.1 Intravenous Injections (IV Bolus and Infusion).................. 31 1.5.2.2 Intra-Arterial Injection........................................................ 32 1.6 Biomarkers....................................................................................................... 32 References................................................................................................................... 33 Chapter 2 Mechanisms of Absorption and Permeation of Xenobiotics....................................... 39 2.1 Introduction......................................................................................................39 2.2 Passive Diffusion..............................................................................................40 2.2.1 Transcellular and Paracellular Diffusion............................................40 2.2.1.1 Partition Coefficient............................................................. 42 2.2.1.2 Distribution Coefficient....................................................... 45 2.2.1.3 Diffusion Coefficient...........................................................46 2.2.1.4 Permeation and Permeability Constant...............................48 2.2.1.5 Estimation of Apparent Permeability Constant Using Caco-2 Cell..........................................................................50 2.2.2 Carrier-Mediated Transcellular Diffusion.......................................... 51 2.3 Transcellular Diffusion Subject to P-Glycoprotein Efflux............................... 52 2.3.1 Pgp Structure and Function................................................................. 53 2.3.2 Pgp Computational Equations............................................................. 55 2.4 Active Transport............................................................................................... 58 2.5 Endocytosis and Pinocytosis............................................................................60 2.6 Solvent Drag, Osmosis, and Two-Pore Theory................................................60 2.7 Ion-Pair Absorption.......................................................................................... 62 References...................................................................................................................64  QQ截图20150503120854.jpg |
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