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2. Cell proliferation inhibition induced by cordycepin
It is important to understand how cordycepin inhibits cell
proliferation in tumor cells in order to develop as a new medicine for cancer prevention and treatment. The A3 adenosine receptor (A3AR)
is a member of the AR family; it is overexpressed in cancer
and inflammatory cells, however, low expression is exhibited
in normal cells (25). Following cordycepin binding to A3AR,
G protein is activated and subsequently inhibits the formation
of  cAMP  and  indirectly  decreases  phosphorylation  of  the
serine/threonine kinase glycogen synthase kinase (GSK)‑3¦Â.
The resulting increased phosphorylation of ¦Â-catenin causes it
to be removed from the cytoplasm by ubiquitination, thereby
preventing its nuclear import. A net suppression of cyclin D1
and c‑myc is the result of this, which leads to the inhibition of
cell growth (Fig. 1) (26). From above analysis, we may safely draw the conclusion that inhibiting cancer/tumor cell proliferation is one of cordycepin function.
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¸ßÌìÉÏÊ¥: ½ð±Ò+3 2015-05-01 08:07:58
Based on the analysis above, we could come to/reach a conclusion that inhibiting cancer/tumor cell proliferation is one of the functions of Cordycepin.
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¸ßÌìÉÏÊ¥: ½ð±Ò+10 2015-05-01 08:07:33
Owing to/Since ......, we may safely draw the conclusion that inhibiting cancer/tumor cell proliferation is one of the cordycepin function
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