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ÊéÃûAntitargets and Drug
Safety
×÷ÕßL¨¢szl¨® Urb¨¢n, Vinod F. Patel,
and Roy J. Vaz
³ö°æÉç wiley
Ò³Êý527
Print ISBN: 978-3-527-33511-4
ePDF ISBN: 978-3-527-67367-4
ePub ISBN: 978-3-527-67366-7
Mobi ISBN: 978-3-527-67365-0
oBook ISBN: 978-3-527-67364-3Contents
List of Contributors XV
Preface XXI
A Personal Foreword XXIII
Section 1 General Concept for Target-based Safety Assessment 1
1 Side Effects of Marketed Drugs: The Utility and Pitfalls
of Pharmacovigilance 3
Steven Whitebread, Mateusz Maciejewski, Alexander Fekete,
Eugen Lounkine, and L¨¢szl¨® Urb¨¢n
1.1 Introduction 3
1.2 Postmarketing Pharmacovigilance 6
1.3 Polypharmacy and Pharmacological Promiscuity of Marketed
Drugs 9
References 15
2 In Silico Prediction of Drug Side Effects 19
Michael J. Keiser
2.1 Large-Scale Prediction of Drug Activity 20
2.1.1 Networks of Known and New Target Activity 21
2.1.1.1 Predicting Drug Off-Targets by Statistical Chemical Similarity 21
2.1.1.2 Representing Drugs Computationally for Rapid Comparison 23
2.1.2 Resources for Multiscale Inquiry 25
2.1.2.1 Ligands to Targets 25
2.1.2.2 Perturbing Biological Systems (Phenotypes) 25
2.1.2.3 Functional and Biological Annotations (Diseases) 27
2.1.2.4 Adverse Reactions as Drug-Induced Diseases 29
2.2 Multiscale Models of Adverse Drug Reactions 30
2.2.1 Inferring Adverse Reactions 31
2.2.1.1 From Off-Targets to Antitargets 31
2.2.1.2 Systematic Antitarget Prediction and Testing 32
2.2.1.3 Finding Side Effects sans Targets 33
2.2.2 Forward Perturbation and Prediction of Mechanisms 33
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  • ¸½¼þ 1 : (Methods_and_Principles_in_Medicinal_Chemistry)_Laszlo_Urban__Vinod_Patel__.pdf
  • 2015-04-26 14:45:21, 27.75 M

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